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The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling.
Atanes P, Lacivita E, Rodríguez J, Brea J, Burgueño J, Vela JM, Cadavid MI, Loza MI, Leopoldo M, Castro M. Atanes P, et al. Among authors: vela jm. Pharmacol Res Perspect. 2013 Dec;1(2):e00013. doi: 10.1002/prp2.13. Epub 2013 Dec 5. Pharmacol Res Perspect. 2013. PMID: 25505568 Free PMC article.
5-HT6 receptor signal transduction second messenger systems.
Codony X, Burgueño J, Ramírez MJ, Vela JM. Codony X, et al. Among authors: vela jm. Int Rev Neurobiol. 2010;94:89-110. doi: 10.1016/B978-0-12-384976-2.00004-6. Int Rev Neurobiol. 2010. PMID: 21081203 Review. No abstract available.
Pharmacological properties of S1RA, a new sigma-1 receptor antagonist that inhibits neuropathic pain and activity-induced spinal sensitization.
Romero L, Zamanillo D, Nadal X, Sánchez-Arroyos R, Rivera-Arconada I, Dordal A, Montero A, Muro A, Bura A, Segalés C, Laloya M, Hernández E, Portillo-Salido E, Escriche M, Codony X, Encina G, Burgueño J, Merlos M, Baeyens JM, Giraldo J, López-García JA, Maldonado R, Plata-Salamán CR, Vela JM. Romero L, et al. Among authors: vela jm. Br J Pharmacol. 2012 Aug;166(8):2289-306. doi: 10.1111/j.1476-5381.2012.01942.x. Br J Pharmacol. 2012. PMID: 22404321 Free PMC article.
124 results