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A GABAergic cortical deficit dominates schizophrenia pathophysiology.
Costa E, Davis JM, Dong E, Grayson DR, Guidotti A, Tremolizzo L, Veldic M. Costa E, et al. Among authors: veldic m. Crit Rev Neurobiol. 2004;16(1-2):1-23. doi: 10.1615/critrevneurobiol.v16.i12.10. Crit Rev Neurobiol. 2004. PMID: 15581395 Review.
An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes.
Zhubi A, Veldic M, Puri NV, Kadriu B, Caruncho H, Loza I, Sershen H, Lajtha A, Smith RC, Guidotti A, Davis JM, Costa E. Zhubi A, et al. Among authors: veldic m. Schizophr Res. 2009 Jun;111(1-3):115-22. doi: 10.1016/j.schres.2009.03.020. Epub 2009 Apr 21. Schizophr Res. 2009. PMID: 19386473 Free PMC article.
Epigenetic targets in GABAergic neurons to treat schizophrenia.
Costa E, Dong E, Grayson DR, Ruzicka WB, Simonini MV, Veldic M, Guidotti A. Costa E, et al. Among authors: veldic m. Adv Pharmacol. 2006;54:95-117. doi: 10.1016/s1054-3589(06)54005-0. Adv Pharmacol. 2006. PMID: 17175812 Review. No abstract available.
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