Venkatakrishnan K - Search Results

1

Drug-drug interactions via mechanism-based cytochrome P450 inactivation: points to consider for risk assessment from in vitro data and clinical pharmacologic evaluation.

Venkatakrishnan K, Obach RS. Venkatakrishnan K, et al. Curr Drug Metab. 2007 Jun;8(5):449-62. doi: 10.2174/138920007780866861. Curr Drug Metab. 2007. PMID: 17584016

2

Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs.

Venkatakrishnan K, von Moltke LL, Greenblatt DJ. Venkatakrishnan K, et al. J Clin Pharmacol. 1999 Jun;39(6):567-77. doi: 10.1177/00912709922008173. J Clin Pharmacol. 1999. PMID: 10354960

3

Effects of the antifungal agents on oxidative drug metabolism: clinical relevance.

Venkatakrishnan K, von Moltke LL, Greenblatt DJ. Venkatakrishnan K, et al. Clin Pharmacokinet. 2000 Feb;38(2):111-80. doi: 10.2165/00003088-200038020-00002. Clin Pharmacokinet. 2000. PMID: 10709776 Review.

4

Evidence for propofol hydroxylation by cytochrome P4502B11 in canine liver microsomes: breed and gender differences.

Hay Kraus BL, Greenblatt DJ, Venkatakrishnan K, Court MH. Hay Kraus BL, et al. Among authors: venkatakrishnan k. Xenobiotica. 2000 Jun;30(6):575-88. doi: 10.1080/004982500406417. Xenobiotica. 2000. PMID: 10923860

5

CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants.

Hesse LM, Venkatakrishnan K, Court MH, von Moltke LL, Duan SX, Shader RI, Greenblatt DJ. Hesse LM, et al. Among authors: venkatakrishnan k. Drug Metab Dispos. 2000 Oct;28(10):1176-83. Drug Metab Dispos. 2000. PMID: 10997936

6

Comparison between cytochrome P450 (CYP) content and relative activity approaches to scaling from cDNA-expressed CYPs to human liver microsomes: ratios of accessory proteins as sources of discrepancies between the approaches.

Venkatakrishnan K, von Moltke LL, Court MH, Harmatz JS, Crespi CL, Greenblatt DJ. Venkatakrishnan K, et al. Drug Metab Dispos. 2000 Dec;28(12):1493-504. Drug Metab Dispos. 2000. PMID: 11095589

7

CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.

Hesse LM, Venkatakrishnan K, von Moltke LL, Shader RI, Greenblatt DJ. Hesse LM, et al. Among authors: venkatakrishnan k. Drug Metab Dispos. 2001 Feb;29(2):133-40. Drug Metab Dispos. 2001. PMID: 11159802

8

Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate.

Venkatakrishnan K, von Moltke LL, Greenblatt DJ. Venkatakrishnan K, et al. J Pharmacol Exp Ther. 2001 Apr;297(1):326-37. J Pharmacol Exp Ther. 2001. PMID: 11259560

9

Relative contribution of CYP3A to amitriptyline clearance in humans: in vitro and in vivo studies.

Venkatakrishnan K, Schmider J, Harmatz JS, Ehrenberg BL, von Moltke LL, Graf JA, Mertzanis P, Corbett KE, Rodriguez MC, Shader RI, Greenblatt DJ. Venkatakrishnan K, et al. J Clin Pharmacol. 2001 Oct;41(10):1043-54. doi: 10.1177/00912700122012634. J Clin Pharmacol. 2001. PMID: 11583471 Clinical Trial.

10

Human drug metabolism and the cytochromes P450: application and relevance of in vitro models.

Venkatakrishnan K, Von Moltke LL, Greenblatt DJ. Venkatakrishnan K, et al. J Clin Pharmacol. 2001 Nov;41(11):1149-79. doi: 10.1177/00912700122012724. J Clin Pharmacol. 2001. PMID: 11697750 Review.

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