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Age-related structural and functional changes of brain mitochondria.
Toescu EC, Myronova N, Verkhratsky A. Toescu EC, et al. Cell Calcium. 2000 Nov-Dec;28(5-6):329-38. doi: 10.1054/ceca.2000.0167. Cell Calcium. 2000. PMID: 11115372 Review.
Normal ageing is associated with a gradual decline in the capacity of various cell types, including neurones, to respond to metabolic stress and return to the resting state. ...
Normal ageing is associated with a gradual decline in the capacity of various cell types, including neurones, to respond to metabolic …
Ion channels in glial cells.
Verkhratsky A, Steinhäuser C. Verkhratsky A, et al. Brain Res Brain Res Rev. 2000 Apr;32(2-3):380-412. doi: 10.1016/s0165-0173(99)00093-4. Brain Res Brain Res Rev. 2000. PMID: 10760549 Review.
The traditional image of the glial cell as a passive, structural element of the nervous system was transformed into the concept of a plastic cell, capable of expressing a large variety of ion channels and neurotransmitter receptors. ...A majority of av …
The traditional image of the glial cell as a passive, structural element of the nervous system was transformed into the concept of …
Assessment of mitochondrial polarization status in living cells based on analysis of the spatial heterogeneity of rhodamine 123 fluorescence staining.
Toescu EC, Verkhratsky A. Toescu EC, et al. Pflugers Arch. 2000 Oct;440(6):941-7. doi: 10.1007/s004240000390. Pflugers Arch. 2000. PMID: 11041562
Collapse of the psimito following exposure to a protonophore, carbonylcyanide p-chloromethoxyphenylhydrazone (CCCP), released rhodamine 123 from mitochondria into the cytosol. ...Thus, the degree of spatial heterogeneity of the rhodamine 123 signal measured from a n …
Collapse of the psimito following exposure to a protonophore, carbonylcyanide p-chloromethoxyphenylhydrazone (CCCP), released rhodami …
Neuronal ageing in long-term cultures: alterations of Ca2+ homeostasis.
Toescu EC, Verkhratsky A. Toescu EC, et al. Neuroreport. 2000 Nov 27;11(17):3725-9. doi: 10.1097/00001756-200011270-00027. Neuroreport. 2000. PMID: 11117480
In neurons aged in culture (DIV 23), a small decrease in the resting [Ca2+]i was associated with a decrease in the maximal rate of [Ca2+]i increase upon KCl-induced depolarization and in the amplitude of the [Ca2+]i response, when compared with mature neurons (DIV 9 …
In neurons aged in culture (DIV 23), a small decrease in the resting [Ca2+]i was associated with a decrease in the maximal rat …
Parameters of calcium homeostasis in normal neuronal ageing.
Toescu EC, Verkhratsky A. Toescu EC, et al. J Anat. 2000 Nov;197 Pt 4(Pt 4):563-9. doi: 10.1046/j.1469-7580.2000.19740563.x. J Anat. 2000. PMID: 11197529 Free PMC article. Review.
The last decade has witnessed a significant turn in our understanding of the mechanisms responsible for the decline of cognitive functions in aged brain. ...It is conceivable that these prolonged Ca2+ signals may exert a local excitotoxic effect, removing preferenti …
The last decade has witnessed a significant turn in our understanding of the mechanisms responsible for the decline of cognitive func …
The endoplasmic reticulum is a focal point for co-ordination of cellular activity.
Bootman MD, Petersen OH, Verkhratsky A. Bootman MD, et al. Cell Calcium. 2002 Nov-Dec;32(5-6):231-4. doi: 10.1016/s0143416002002002. Cell Calcium. 2002. PMID: 12543085 Review. No abstract available.
The endoplasmic reticulum and neuronal calcium signalling.
Verkhratsky A. Verkhratsky A. Cell Calcium. 2002 Nov-Dec;32(5-6):393-404. doi: 10.1016/s0143416002001896. Cell Calcium. 2002. PMID: 12543098 Review.
The endoplasmic reticulum (ER) is a multifunctional signalling organelle regulating a wide range of neuronal functional responses. ...At the same time, the ER Ca(2+) store emerges as a single interconnected pool fenced by the endomembrane. The continuity of t …
The endoplasmic reticulum (ER) is a multifunctional signalling organelle regulating a wide range of neuronal functional respon …
Neuronal ageing from an intraneuronal perspective: roles of endoplasmic reticulum and mitochondria.
Toescu EC, Verkhratsky A. Toescu EC, et al. Cell Calcium. 2003 Oct-Nov;34(4-5):311-23. doi: 10.1016/s0143-4160(03)00142-8. Cell Calcium. 2003. PMID: 12909078 Review.
In this paper, we review the changes in neuronal Ca(2+) homeostasis that occur during brain ageing, and conclude that normal, physiological ageing is characterised mainly by a decrease of neuronal homeostatic reserve, defined as the capacity to respond effectively to funct …
In this paper, we review the changes in neuronal Ca(2+) homeostasis that occur during brain ageing, and conclude that normal, physiological …
Two centuries of excitation-contraction coupling.
Wray S, Ravens U, Verkhratsky A, Eisner D. Wray S, et al. Cell Calcium. 2004 Jun;35(6):485-9. doi: 10.1016/j.ceca.2004.01.004. Cell Calcium. 2004. PMID: 15110138 Review. No abstract available.
Ca2+ and mitochondria as substrates for deficits in synaptic plasticity in normal brain ageing.
Toescu EC, Verkhratsky A. Toescu EC, et al. J Cell Mol Med. 2004 Apr-Jun;8(2):181-90. doi: 10.1111/j.1582-4934.2004.tb00273.x. J Cell Mol Med. 2004. PMID: 15256066 Free PMC article. Review.
Normal brain ageing is associated with a degree of functional impairment of neuronal activity that results in a reduction in memory and cognitive functions. One mechanism proposed to explain the age-dependent changes was the "Ca(2+) hypothesis of ageing" but data ac …
Normal brain ageing is associated with a degree of functional impairment of neuronal activity that results in a reduction in m …
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