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Physiologically Based Pharmacokinetic Predictions of Tramadol Exposure Throughout Pediatric Life: an Analysis of the Different Clearance Contributors with Emphasis on CYP2D6 Maturation.
T'jollyn H, Snoeys J, Vermeulen A, Michelet R, Cuyckens F, Mannens G, Van Peer A, Annaert P, Allegaert K, Van Bocxlaer J, Boussery K. T'jollyn H, et al. Among authors: vermeulen a. AAPS J. 2015 Nov;17(6):1376-87. doi: 10.1208/s12248-015-9803-z. Epub 2015 Jul 25. AAPS J. 2015. PMID: 26209290 Free PMC article.
Strategies for Determining Correct Cytochrome P450 Contributions in Hepatic Clearance Predictions: In Vitro-In Vivo Extrapolation as Modelling Approach and Tramadol as Proof-of Concept Compound.
T'jollyn H, Snoeys J, Van Bocxlaer J, De Bock L, Annaert P, Van Peer A, Allegaert K, Mannens G, Vermeulen A, Boussery K. T'jollyn H, et al. Among authors: vermeulen a. Eur J Drug Metab Pharmacokinet. 2017 Jun;42(3):537-543. doi: 10.1007/s13318-016-0355-0. Eur J Drug Metab Pharmacokinet. 2017. PMID: 27317395
General clinical and methodological considerations on the extrapolation of pharmacokinetics and optimization of study protocols for small molecules and monoclonal antibodies in children.
Bouazza N, Dokoumetzidis A, Knibbe CAJ, de Wildt SN, Ambery C, De Cock PA, Gasthuys E, Foissac F, Urien S, Hamberg AK, Poggesi I, Zhao W, Vermeulen A, Standing JF, Tréluyer JM; c4c Expert group on Pharmacometrics. Bouazza N, et al. Among authors: vermeulen a. Br J Clin Pharmacol. 2022 Dec;88(12):4985-4996. doi: 10.1111/bcp.15571. Epub 2022 Nov 8. Br J Clin Pharmacol. 2022. PMID: 36256514 Free article. Review.
Physiology-based IVIVE predictions of tramadol from in vitro metabolism data.
T'jollyn H, Snoeys J, Colin P, Van Bocxlaer J, Annaert P, Cuyckens F, Vermeulen A, Van Peer A, Allegaert K, Mannens G, Boussery K. T'jollyn H, et al. Among authors: vermeulen a. Pharm Res. 2015 Jan;32(1):260-74. doi: 10.1007/s11095-014-1460-x. Epub 2014 Jul 22. Pharm Res. 2015. PMID: 25048637
Predicting Drug Concentration-Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically-Based Pharmacokinetic Model.
Yamamoto Y, Välitalo PA, Huntjens DR, Proost JH, Vermeulen A, Krauwinkel W, Beukers MW, van den Berg DJ, Hartman R, Wong YC, Danhof M, van Hasselt JGC, de Lange ECM. Yamamoto Y, et al. Among authors: vermeulen a. CPT Pharmacometrics Syst Pharmacol. 2017 Nov;6(11):765-777. doi: 10.1002/psp4.12250. Epub 2017 Oct 13. CPT Pharmacometrics Syst Pharmacol. 2017. PMID: 28891201 Free PMC article.
798 results