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Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.
Wormhoudt LW, Commandeur JN, Vermeulen NP. Wormhoudt LW, et al. Among authors: vermeulen np. Crit Rev Toxicol. 1999 Jan;29(1):59-124. doi: 10.1080/10408449991349186. Crit Rev Toxicol. 1999. PMID: 10066160 Review.
Studies on the inhibition of human cytochromes P450 by selenocysteine Se-conjugates.
Venhorst J, Rooseboom M, Vermeulen NP, Commandeur JN. Venhorst J, et al. Among authors: vermeulen np. Xenobiotica. 2003 Jan;33(1):57-72. doi: 10.1080/0049825021000022357. Xenobiotica. 2003. PMID: 12519694
ETAP changes.
Vermeulen NP, Seegal RF, Koeman JH. Vermeulen NP, et al. Environ Toxicol Pharmacol. 2001 Jun;10(1-2):V. doi: 10.1016/s1382-6689(01)00086-2. Environ Toxicol Pharmacol. 2001. PMID: 11382557 No abstract available.
Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites.
Boerma JS, Vermeulen NP, Commandeur JN. Boerma JS, et al. Among authors: vermeulen np. Chem Res Toxicol. 2011 Aug 15;24(8):1263-74. doi: 10.1021/tx2001515. Epub 2011 Jun 16. Chem Res Toxicol. 2011. PMID: 21639118
Biotransformation of endocrine disrupting compounds by selected phase I and phase II enzymes--formation of estrogenic and chemically reactive metabolites by cytochromes P450 and sulfotransferases.
Reinen J, Vermeulen NP. Reinen J, et al. Among authors: vermeulen np. Curr Med Chem. 2015;22(4):500-27. doi: 10.2174/0929867321666140916123022. Curr Med Chem. 2015. PMID: 25245506 Review.
Inhibition of human glutathione S-transferases by curcumin and analogues.
Appiah-Opong R, Commandeur JN, Istyastono E, Bogaards JJ, Vermeulen NP. Appiah-Opong R, et al. Among authors: vermeulen np. Xenobiotica. 2009 Apr;39(4):302-11. doi: 10.1080/00498250802702316. Xenobiotica. 2009. PMID: 19350453
Metabolism of N-substituted 7-methoxy-4-(aminomethyl) -coumarins by cytochrome P450 2D6 mutants and the indication of additional substrate interaction points.
Keizers PH, Van Dijk BR, De Graaf C, Van Vugt-Lussenburg BM, Vermeulen NP, Commandeur JN. Keizers PH, et al. Among authors: vermeulen np. Xenobiotica. 2006 Sep;36(9):763-71. doi: 10.1080/00498250600765325. Xenobiotica. 2006. PMID: 16971342
Bioactivation of N-substituted N'-(4-imidazole-ethyl)thioureas by human FMO1 and FMO3.
Onderwater RC, Rettie AE, Commandeur JN, Vermeulen NP. Onderwater RC, et al. Among authors: vermeulen np. Xenobiotica. 2006 Jul;36(7):645-57. doi: 10.1080/00498250500354329. Xenobiotica. 2006. PMID: 16864509
On-line formation, separation, and estrogen receptor affinity screening of cytochrome P450-derived metabolites of selective estrogen receptor modulators.
van Liempd SM, Kool J, Niessen WM, van Elswijk DE, Irth H, Vermeulen NP. van Liempd SM, et al. Among authors: vermeulen np. Drug Metab Dispos. 2006 Sep;34(9):1640-9. doi: 10.1124/dmd.106.010355. Epub 2006 Jun 21. Drug Metab Dispos. 2006. PMID: 16790557
Uptake-toxicity relationships of a series of N-substituted N'-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices.
Onderwater RC, Commandeur JN, Rooseboom M, Vermeulen NP. Onderwater RC, et al. Among authors: vermeulen np. Xenobiotica. 2005 Apr;35(4):391-404. doi: 10.1080/00498250500066154. Xenobiotica. 2005. PMID: 16019959
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