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NOTCH1 modulates activity of DNA-PKcs.
Adamowicz M, d'Adda di Fagagna F, Vermezovic J. Adamowicz M, et al. Among authors: vermezovic j. Mutat Res. 2018 Mar;808:20-27. doi: 10.1016/j.mrfmmm.2018.01.003. Mutat Res. 2018. PMID: 29482073
The transcription factor PREP1(PKNOX1) regulates nuclear stiffness, the expression of LINC complex proteins and mechanotransduction.
Purushothaman D, Bianchi LF, Penkov D, Poli A, Li Q, Vermezovic J, Pramotton FM, Choudhary R, Pennacchio FA, Sommariva E, Foiani M, Gauthier N, Maiuri P, Blasi F. Purushothaman D, et al. Among authors: vermezovic j. Commun Biol. 2022 May 12;5(1):456. doi: 10.1038/s42003-022-03406-9. Commun Biol. 2022. PMID: 35550602 Free PMC article.
Notch is a direct negative regulator of the DNA-damage response.
Vermezovic J, Adamowicz M, Santarpia L, Rustighi A, Forcato M, Lucano C, Massimiliano L, Costanzo V, Bicciato S, Del Sal G, d'Adda di Fagagna F. Vermezovic J, et al. Nat Struct Mol Biol. 2015 May;22(5):417-24. doi: 10.1038/nsmb.3013. Epub 2015 Apr 20. Nat Struct Mol Biol. 2015. PMID: 25895060 Free article.