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TLRs as therapeutic targets in CNS inflammation and infection.
Pedras-Vasconcelos J, Puig M, Verthelyi D. Pedras-Vasconcelos J, et al. Front Biosci (Elite Ed). 2009 Jun 1;1:476-87. doi: 10.2741/e43. Front Biosci (Elite Ed). 2009. PMID: 19482661 Review.
CpG DNA: recognition by and activation of monocytes.
Klinman DM, Takeshita F, Gursel I, Leifer C, Ishii KJ, Verthelyi D, Gursel M. Klinman DM, et al. Microbes Infect. 2002 Jul;4(9):897-901. doi: 10.1016/s1286-4579(02)01614-3. Microbes Infect. 2002. PMID: 12106782 Review.
In contrast, "D"-type ODNs trigger monocytes to differentiate into mature dendritic cells....
In contrast, "D"-type ODNs trigger monocytes to differentiate into mature dendritic cells....
CpG oligodeoxynucleotides induce human monocytes to mature into functional dendritic cells.
Gursel M, Verthelyi D, Klinman DM. Gursel M, et al. Eur J Immunol. 2002 Sep;32(9):2617-22. doi: 10.1002/1521-4141(200209)32:9<2617::AID-IMMU2617>3.0.CO;2-F. Eur J Immunol. 2002. PMID: 12207346
Current results demonstrate that the recently identified "D" type of CpG ODN stimulate human peripheral blood monocytes to mature into functionally active DC over 2-4 days. ...The differentiation of these monocytes is mediated by plasmacytoid DC, which respond to D
Current results demonstrate that the recently identified "D" type of CpG ODN stimulate human peripheral blood monocytes to mature int …
Differential signaling by CpG DNA in DCs and B cells: not just TLR9.
Verthelyi D, Zeuner RA. Verthelyi D, et al. Trends Immunol. 2003 Oct;24(10):519-22. doi: 10.1016/s1471-4906(03)00243-6. Trends Immunol. 2003. PMID: 14552833 Review.
Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates.
Verthelyi D, Klinman DM. Verthelyi D, et al. Clin Immunol. 2003 Oct;109(1):64-71. doi: 10.1016/s1521-6616(03)00202-x. Clin Immunol. 2003. PMID: 14585277 Review.
D-type ODN trigger plasmacytoid DC to secrete IFNalpha, monocytes to mature into functionally active DC, and NK cells to secrete IFNgamma. ...
D-type ODN trigger plasmacytoid DC to secrete IFNalpha, monocytes to mature into functionally active DC, and NK cells to secrete IFNg
Prevention and treatment of cutaneous leishmaniasis in primates by using synthetic type D/A oligodeoxynucleotides expressing CpG motifs.
Flynn B, Wang V, Sacks DL, Seder RA, Verthelyi D. Flynn B, et al. Infect Immun. 2005 Aug;73(8):4948-54. doi: 10.1128/IAI.73.8.4948-4954.2005. Infect Immun. 2005. PMID: 16041009 Free PMC article.
In this study, we show that systemic administration of D/A ODN limits the size of lesions following an intradermal infection with L. major. ...Together, these findings support the development of clinical studies to assess the use of CpG ODN types D/A as immunoprotec …
In this study, we show that systemic administration of D/A ODN limits the size of lesions following an intradermal infection with L. …
CpG oligodeoxynucleotides protect newborn mice from a lethal challenge with the neurotropic Tacaribe arenavirus.
Pedras-Vasconcelos JA, Goucher D, Puig M, Tonelli LH, Wang V, Ito S, Verthelyi D. Pedras-Vasconcelos JA, et al. J Immunol. 2006 Apr 15;176(8):4940-9. doi: 10.4049/jimmunol.176.8.4940. J Immunol. 2006. PMID: 16585590
Adjuvant properties of CpG oligonucleotides in primates.
Verthelyi D. Verthelyi D. Methods Mol Med. 2006;127:139-58. doi: 10.1385/1-59745-168-1:139. Methods Mol Med. 2006. PMID: 16988453 Review.
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