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Targeting zinc homeostasis to combat Aspergillus fumigatus infections.
Vicentefranqueira R, Amich J, Laskaris P, Ibrahim-Granet O, Latgé JP, Toledo H, Leal F, Calera JA. Vicentefranqueira R, et al. Front Microbiol. 2015 Feb 27;6:160. doi: 10.3389/fmicb.2015.00160. eCollection 2015. Front Microbiol. 2015. PMID: 25774155 Free PMC article.
A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism.
Laskaris P, Vicentefranqueira R, Helynck O, Jouvion G, Calera JA, du Merle L, Suzenet F, Buron F, de Sousa RA, Mansuy D, Cavaillon JM, Latgé JP, Munier-Lehmann H, Ibrahim-Granet O. Laskaris P, et al. Among authors: vicentefranqueira r. Antimicrob Agents Chemother. 2018 May 25;62(6):e02510-17. doi: 10.1128/AAC.02510-17. Print 2018 Jun. Antimicrob Agents Chemother. 2018. PMID: 29632009 Free PMC article.
The interplay between zinc and iron homeostasis in Aspergillus fumigatus under zinc-replete conditions relies on the iron-mediated regulation of alternative transcription units of zafA and the basal amount of the ZafA zinc-responsiveness transcription factor.
Vicentefranqueira R, Leal F, Marín L, Sánchez CI, Calera JA. Vicentefranqueira R, et al. Environ Microbiol. 2019 Aug;21(8):2787-2808. doi: 10.1111/1462-2920.14618. Epub 2019 Apr 26. Environ Microbiol. 2019. PMID: 30946522