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CD4+ T-cell depletion in HIV infection: are we closer to understanding the cause?
Grossman Z, Meier-Schellersheim M, Sousa AE, Victorino RM, Paul WE. Grossman Z, et al. Among authors: victorino rm. Nat Med. 2002 Apr;8(4):319-23. doi: 10.1038/nm0402-319. Nat Med. 2002. PMID: 11927927 No abstract available.
CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load.
Sousa AE, Carneiro J, Meier-Schellersheim M, Grossman Z, Victorino RM. Sousa AE, et al. Among authors: victorino rm. J Immunol. 2002 Sep 15;169(6):3400-6. doi: 10.4049/jimmunol.169.6.3400. J Immunol. 2002. PMID: 12218162
Gag-specific CD4+ T-cell frequency is inversely correlated with proviral load and directly correlated with immune activation in infection with human immunodeficiency virus type 2 (HIV-2) but not HIV-1.
Foxall RB, Cortesão CS, Albuquerque AS, Soares RS, Victorino RM, Sousa AE. Foxall RB, et al. Among authors: victorino rm. J Virol. 2008 Oct;82(19):9795-9. doi: 10.1128/JVI.01217-08. Epub 2008 Jul 23. J Virol. 2008. PMID: 18653457 Free PMC article.
Memory and naive-like regulatory CD4+ T cells expand during HIV-2 infection in direct association with CD4+ T-cell depletion irrespectively of viremia.
Foxall RB, Albuquerque AS, Soares RS, Baptista AP, Cavaleiro R, Tendeiro R, Gomes P, Victorino RM, Sousa AE. Foxall RB, et al. Among authors: victorino rm. AIDS. 2011 Oct 23;25(16):1961-70. doi: 10.1097/QAD.0b013e32834b3554. AIDS. 2011. PMID: 21811143
Increased frequency of circulating CCR5+ CD4+ T cells in human immunodeficiency virus type 2 infection.
Soares R, Foxall R, Albuquerque A, Cortesão C, Garcia M, Victorino RM, Sousa AE. Soares R, et al. Among authors: victorino rm. J Virol. 2006 Dec;80(24):12425-9. doi: 10.1128/JVI.01557-06. Epub 2006 Oct 11. J Virol. 2006. PMID: 17035326 Free PMC article.
Low CD4 T-cell counts despite low levels of circulating HIV: insights from the comparison of HIV-1 infected patients with a discordant response to antiretroviral therapy to patients with untreated advanced HIV-2 disease.
Albuquerque AS, Foxall RB, Cortesão CS, Soares RS, Doroana M, Ribeiro A, Lucas M, Antunes F, Victorino RM, Sousa AE. Albuquerque AS, et al. Among authors: victorino rm. Clin Immunol. 2007 Oct;125(1):67-75. doi: 10.1016/j.clim.2007.07.001. Epub 2007 Aug 9. Clin Immunol. 2007. PMID: 17692571
Major depletion of plasmacytoid dendritic cells in HIV-2 infection, an attenuated form of HIV disease.
Cavaleiro R, Baptista AP, Soares RS, Tendeiro R, Foxall RB, Gomes P, Victorino RM, Sousa AE. Cavaleiro R, et al. Among authors: victorino rm. PLoS Pathog. 2009 Nov;5(11):e1000667. doi: 10.1371/journal.ppat.1000667. Epub 2009 Nov 20. PLoS Pathog. 2009. PMID: 19936055 Free PMC article.
PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia.
Tendeiro R, Foxall RB, Baptista AP, Pinto F, Soares RS, Cavaleiro R, Valadas E, Gomes P, Victorino RM, Sousa AE. Tendeiro R, et al. Among authors: victorino rm. AIDS. 2012 Jun 1;26(9):1065-71. doi: 10.1097/QAD.0b013e32835374db. AIDS. 2012. PMID: 22441249
Delta-like 1-mediated Notch signaling enhances the in vitro conversion of human memory CD4 T cells into FOXP3-expressing regulatory T cells.
Mota C, Nunes-Silva V, Pires AR, Matoso P, Victorino RM, Sousa AE, Caramalho I. Mota C, et al. Among authors: victorino rm. J Immunol. 2014 Dec 15;193(12):5854-62. doi: 10.4049/jimmunol.1400198. Epub 2014 Nov 3. J Immunol. 2014. PMID: 25367118
Massive hypereosinophilia and vasculitis associated with major expansion of interleukin-5-producing CD8+ T cells in HIV-1 infection.
Jorge I, Amaral B, Soares-Almeida LM, Foxall RB, Tendeiro R, Santos JM, Sousa AE, Victorino RM. Jorge I, et al. Among authors: victorino rm. AIDS. 2014 Apr 24;28(7):1075-7. doi: 10.1097/QAD.0000000000000205. AIDS. 2014. PMID: 24685745 No abstract available.
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