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Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy.
Vigna E, Naldini L. Vigna E, et al. J Gene Med. 2000 Sep-Oct;2(5):308-16. doi: 10.1002/1521-2254(200009/10)2:5<308::AID-JGM131>3.0.CO;2-3. J Gene Med. 2000. PMID: 11045424 Review.
Molecular Engineering Strategies Tailoring the Apoptotic Response to a MET Therapeutic Antibody.
Modica C, Gallo S, Chiriaco C, Spilinga M, Comoglio PM, Crepaldi T, Basilico C, Vigna E. Modica C, et al. Among authors: vigna e. Cancers (Basel). 2020 Mar 21;12(3):741. doi: 10.3390/cancers12030741. Cancers (Basel). 2020. PMID: 32245152 Free PMC article.
Robust and efficient regulation of transgene expression in vivo by improved tetracycline-dependent lentiviral vectors.
Vigna E, Cavalieri S, Ailles L, Geuna M, Loew R, Bujard H, Naldini L. Vigna E, et al. Mol Ther. 2002 Mar;5(3):252-61. doi: 10.1006/mthe.2002.0542. Mol Ther. 2002. PMID: 11863414
Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters.
Amendola M, Venneri MA, Biffi A, Vigna E, Naldini L. Amendola M, et al. Among authors: vigna e. Nat Biotechnol. 2005 Jan;23(1):108-16. doi: 10.1038/nbt1049. Epub 2004 Dec 26. Nat Biotechnol. 2005. PMID: 15619618
Efficient Tet-dependent expression of human factor IX in vivo by a new self-regulating lentiviral vector.
Vigna E, Amendola M, Benedicenti F, Simmons AD, Follenzi A, Naldini L. Vigna E, et al. Mol Ther. 2005 May;11(5):763-75. doi: 10.1016/j.ymthe.2004.11.017. Mol Ther. 2005. PMID: 15851015
MET overexpression turns human primary osteoblasts into osteosarcomas.
Patanè S, Avnet S, Coltella N, Costa B, Sponza S, Olivero M, Vigna E, Naldini L, Baldini N, Ferracini R, Corso S, Giordano S, Comoglio PM, Di Renzo MF. Patanè S, et al. Among authors: vigna e. Cancer Res. 2006 May 1;66(9):4750-7. doi: 10.1158/0008-5472.CAN-05-4422. Cancer Res. 2006. PMID: 16651428
"Active" cancer immunotherapy by anti-Met antibody gene transfer.
Vigna E, Pacchiana G, Mazzone M, Chiriaco C, Fontani L, Basilico C, Pennacchietti S, Comoglio PM. Vigna E, et al. Cancer Res. 2008 Nov 15;68(22):9176-83. doi: 10.1158/0008-5472.CAN-08-1688. Cancer Res. 2008. PMID: 19010889
T cell receptor (TCR) gene transfer with lentiviral vectors allows efficient redirection of tumor specificity in naive and memory T cells without prior stimulation of endogenous TCR.
Circosta P, Granziero L, Follenzi A, Vigna E, Stella S, Vallario A, Elia AR, Gammaitoni L, Vitaggio K, Orso F, Geuna M, Sangiolo D, Todorovic M, Giachino C, Cignetti A. Circosta P, et al. Among authors: vigna e. Hum Gene Ther. 2009 Dec;20(12):1576-88. doi: 10.1089/hum.2009.117. Hum Gene Ther. 2009. PMID: 19678763
Targeted therapy by gene transfer of a monovalent antibody fragment against the Met oncogenic receptor.
Vigna E, Pacchiana G, Chiriaco C, Cignetto S, Fontani L, Michieli P, Comoglio PM. Vigna E, et al. J Mol Med (Berl). 2014 Jan;92(1):65-76. doi: 10.1007/s00109-013-1079-0. Epub 2013 Sep 7. J Mol Med (Berl). 2014. PMID: 24013625
Targeting the oncogenic Met receptor by antibodies and gene therapy.
Vigna E, Comoglio PM. Vigna E, et al. Oncogene. 2015 Apr 9;34(15):1883-9. doi: 10.1038/onc.2014.142. Epub 2014 Jun 2. Oncogene. 2015. PMID: 24882574 Review.
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