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404 results
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Bisperoxovanadium compounds are potent PTEN inhibitors.
Schmid AC, Byrne RD, Vilar R, Woscholski R. Schmid AC, et al. Among authors: vilar r. FEBS Lett. 2004 May 21;566(1-3):35-8. doi: 10.1016/j.febslet.2004.03.102. FEBS Lett. 2004. PMID: 15147864
A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN).
Rosivatz E, Matthews JG, McDonald NQ, Mulet X, Ho KK, Lossi N, Schmid AC, Mirabelli M, Pomeranz KM, Erneux C, Lam EW, Vilar R, Woscholski R. Rosivatz E, et al. Among authors: vilar r. ACS Chem Biol. 2006 Dec 15;1(12):780-90. doi: 10.1021/cb600352f. ACS Chem Biol. 2006. PMID: 17240976
Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex.
Reed JE, Neidle S, Vilar R. Reed JE, et al. Among authors: vilar r. Chem Commun (Camb). 2007 Nov 14;(42):4366-8. doi: 10.1039/b709898g. Epub 2007 Aug 13. Chem Commun (Camb). 2007. PMID: 17957288
Stabilisation of G-quadruplex DNA by small molecules.
Arola A, Vilar R. Arola A, et al. Among authors: vilar r. Curr Top Med Chem. 2008;8(15):1405-15. doi: 10.2174/156802608786141106. Curr Top Med Chem. 2008. PMID: 18991726 Review.
Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes.
Georgiades SN, Mak LH, Angurell I, Rosivatz E, Firouz Mohd Mustapa M, Polychroni C, Woscholski R, Vilar R. Georgiades SN, et al. Among authors: vilar r. J Biol Inorg Chem. 2011 Feb;16(2):195-208. doi: 10.1007/s00775-010-0716-0. Epub 2010 Oct 23. J Biol Inorg Chem. 2011. PMID: 20972690
A small molecule mimicking a phosphatidylinositol (4,5)-bisphosphate binding pleckstrin homology domain.
Mak LH, Georgiades SN, Rosivatz E, Whyte GF, Mirabelli M, Vilar R, Woscholski R. Mak LH, et al. Among authors: vilar r. ACS Chem Biol. 2011 Dec 16;6(12):1382-90. doi: 10.1021/cb2003187. Epub 2011 Oct 10. ACS Chem Biol. 2011. PMID: 21958214
A tri-copper(II) complex displaying DNA-cleaving properties and antiproliferative activity against cancer cells.
Suntharalingam K, Hunt DJ, Duarte AA, White AJ, Mann DJ, Vilar R. Suntharalingam K, et al. Among authors: vilar r. Chemistry. 2012 Nov 19;18(47):15133-41. doi: 10.1002/chem.201202482. Epub 2012 Oct 11. Chemistry. 2012. PMID: 23059789
A platinum complex that binds non-covalently to DNA and induces cell death via a different mechanism than cisplatin.
Suntharalingam K, Mendoza O, Duarte AA, Mann DJ, Vilar R. Suntharalingam K, et al. Among authors: vilar r. Metallomics. 2013 May;5(5):514-23. doi: 10.1039/c3mt20252f. Epub 2013 Mar 13. Metallomics. 2013. PMID: 23487034
Vanadyl complexes with dansyl-labelled di-picolinic acid ligands: synthesis, phosphatase inhibition activity and cellular uptake studies.
Collins J, Cilibrizzi A, Fedorova M, Whyte G, Mak LH, Guterman I, Leatherbarrow R, Woscholski R, Vilar R. Collins J, et al. Among authors: vilar r. Dalton Trans. 2016 Apr 28;45(16):7104-13. doi: 10.1039/c5dt04753f. Epub 2016 Mar 23. Dalton Trans. 2016. PMID: 27008377
A tri-functional vanadium(iv) complex to detect cysteine oxidation.
Cilibrizzi A, Fedorova M, Collins J, Leatherbarrow R, Woscholski R, Vilar R. Cilibrizzi A, et al. Among authors: vilar r. Dalton Trans. 2017 May 30;46(21):6994-7004. doi: 10.1039/c7dt00076f. Dalton Trans. 2017. PMID: 28513686
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