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The Mechanistic Links Between Proteasome Activity, Aging and Age-related Diseases.
Saez I, Vilchez D. Saez I, et al. Curr Genomics. 2014 Feb;15(1):38-51. doi: 10.2174/138920291501140306113344. Curr Genomics. 2014. PMID: 24653662 Free PMC article.
Proteostasis and aging of stem cells.
Vilchez D, Simic MS, Dillin A. Vilchez D, et al. Trends Cell Biol. 2014 Mar;24(3):161-70. doi: 10.1016/j.tcb.2013.09.002. Epub 2013 Oct 3. Trends Cell Biol. 2014. PMID: 24094931 Review.
Mediation of organismal aging and somatic proteostasis by the germline.
Khodakarami A, Saez I, Mels J, Vilchez D. Khodakarami A, et al. Front Mol Biosci. 2015 Jan 23;2:3. doi: 10.3389/fmolb.2015.00003. eCollection 2015. Front Mol Biosci. 2015. PMID: 25988171 Free PMC article. Review.
The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.
Rinschen MM, Bharill P, Wu X, Kohli P, Reinert MJ, Kretz O, Saez I, Schermer B, Höhne M, Bartram MP, Aravamudhan S, Brooks BR, Vilchez D, Huber TB, Müller RU, Krüger M, Benzing T. Rinschen MM, et al. Hum Mol Genet. 2016 Apr 1;25(7):1328-44. doi: 10.1093/hmg/ddw016. Epub 2016 Jan 19. Hum Mol Genet. 2016. PMID: 26792178 Free PMC article.
Embryonic stem cells: a novel paradigm to study proteostasis?
Lee HJ, Gutierrez-Garcia R, Vilchez D. Lee HJ, et al. FEBS J. 2017 Feb;284(3):391-398. doi: 10.1111/febs.13810. Epub 2016 Jul 27. FEBS J. 2017. PMID: 27398614 Review.
Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan.
Noormohammadi A, Khodakarami A, Gutierrez-Garcia R, Lee HJ, Koyuncu S, König T, Schindler C, Saez I, Fatima A, Dieterich C, Vilchez D. Noormohammadi A, et al. Nat Commun. 2016 Nov 28;7:13649. doi: 10.1038/ncomms13649. Nat Commun. 2016. PMID: 27892468 Free PMC article.
Mechanisms of protein homeostasis (proteostasis) maintain stem cell identity in mammalian pluripotent stem cells.
Noormohammadi A, Calculli G, Gutierrez-Garcia R, Khodakarami A, Koyuncu S, Vilchez D. Noormohammadi A, et al. Cell Mol Life Sci. 2018 Jan;75(2):275-290. doi: 10.1007/s00018-017-2602-1. Epub 2017 Jul 26. Cell Mol Life Sci. 2018. PMID: 28748323 Review.
Proteostasis of Huntingtin in Health and Disease.
Koyuncu S, Fatima A, Gutierrez-Garcia R, Vilchez D. Koyuncu S, et al. Int J Mol Sci. 2017 Jul 19;18(7):1568. doi: 10.3390/ijms18071568. Int J Mol Sci. 2017. PMID: 28753941 Free PMC article. Review.
Insights into the ubiquitin-proteasome system of human embryonic stem cells.
Saez I, Koyuncu S, Gutierrez-Garcia R, Dieterich C, Vilchez D. Saez I, et al. Sci Rep. 2018 Mar 6;8(1):4092. doi: 10.1038/s41598-018-22384-9. Sci Rep. 2018. PMID: 29511261 Free PMC article.
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