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Mitochondria and lipid raft-located FOF1-ATP synthase as major therapeutic targets in the antileishmanial and anticancer activities of ether lipid edelfosine.
Villa-Pulgarín JA, Gajate C, Botet J, Jimenez A, Justies N, Varela-M RE, Cuesta-Marbán Á, Müller I, Modolell M, Revuelta JL, Mollinedo F. Villa-Pulgarín JA, et al. PLoS Negl Trop Dis. 2017 Aug 22;11(8):e0005805. doi: 10.1371/journal.pntd.0005805. eCollection 2017 Aug. PLoS Negl Trop Dis. 2017. PMID: 28829771 Free PMC article.
In vitro and In vivo selective antitumor activity of Edelfosine against mantle cell lymphoma and chronic lymphocytic leukemia involving lipid rafts.
Mollinedo F, de la Iglesia-Vicente J, Gajate C, Estella-Hermoso de Mendoza A, Villa-Pulgarin JA, de Frias M, Roué G, Gil J, Colomer D, Campanero MA, Blanco-Prieto MJ. Mollinedo F, et al. Clin Cancer Res. 2010 Apr 1;16(7):2046-54. doi: 10.1158/1078-0432.CCR-09-2456. Epub 2010 Mar 16. Clin Cancer Res. 2010. PMID: 20233887
Lipid raft-targeted therapy in multiple myeloma.
Mollinedo F, de la Iglesia-Vicente J, Gajate C, Estella-Hermoso de Mendoza A, Villa-Pulgarin JA, Campanero MA, Blanco-Prieto MJ. Mollinedo F, et al. Oncogene. 2010 Jul 1;29(26):3748-57. doi: 10.1038/onc.2010.131. Epub 2010 Apr 26. Oncogene. 2010. PMID: 20418917
Involvement of lipid rafts in the localization and dysfunction effect of the antitumor ether phospholipid edelfosine in mitochondria.
Mollinedo F, Fernández M, Hornillos V, Delgado J, Amat-Guerri F, Acuña AU, Nieto-Miguel T, Villa-Pulgarín JA, González-García C, Ceña V, Gajate C. Mollinedo F, et al. Among authors: villa pulgarin ja. Cell Death Dis. 2011 May 19;2(5):e158. doi: 10.1038/cddis.2011.41. Cell Death Dis. 2011. PMID: 21593790 Free PMC article.
In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites.
Varela-M RE, Villa-Pulgarin JA, Yepes E, Müller I, Modolell M, Muñoz DL, Robledo SM, Muskus CE, López-Abán J, Muro A, Vélez ID, Mollinedo F. Varela-M RE, et al. Among authors: villa pulgarin ja. PLoS Negl Trop Dis. 2012;6(4):e1612. doi: 10.1371/journal.pntd.0001612. Epub 2012 Apr 10. PLoS Negl Trop Dis. 2012. PMID: 22506086 Free PMC article.
C-Geranylated flavonoids from Paulownia tomentosa fruits with antimicrobial potential and synergistic activity with antibiotics.
Navrátilová A, Nešuta O, Vančatová I, Čížek A, Varela-M RE, López-Abán J, Villa-Pulgarin JA, Mollinedo F, Muro A, Žemličková H, Kadlecová D, Šmejkal K. Navrátilová A, et al. Among authors: villa pulgarin ja. Pharm Biol. 2016 Aug;54(8):1398-407. doi: 10.3109/13880209.2015.1103755. Epub 2016 Jan 20. Pharm Biol. 2016. PMID: 26789098
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