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Regulation of urea synthesis by glucose and glucagon in normal man.
Hamberg O, Vilstrup H. Hamberg O, et al. Clin Nutr. 1994 Jun;13(3):183-91. doi: 10.1016/0261-5614(94)90099-x. Clin Nutr. 1994. PMID: 16843380

During alanine infusion alone FHNC was (mean +/- SEM) 32.5 +/- 1.9 l/h. Glucose reduced FHNC by 43% to 18.4 +/- 0.9 l/h (p < 0.01). The low stepwise glucagon infusion only partially normalized FHNC as reduced by glucose (to 24.6 +/- 1.5 l/h, (p < 0.01 v

During alanine infusion alone FHNC was (mean +/- SEM) 32.5 +/- 1.9 l/h. Glucose reduced FHNC by 43% to 18.4 +/- 0.9 l/h (p &lt …
Effects of an increase in protein intake on hepatic efficacy for urea synthesis in healthy subjects and in patients with cirrhosis.
Hamberg O, Nielsen K, Vilstrup H. Hamberg O, et al. J Hepatol. 1992 Mar;14(2-3):237-43. doi: 10.1016/0168-8278(92)90164-k. J Hepatol. 1992. PMID: 1500687
This increased the hepatic nitrogen clearance from 27 +/- 10 l/h to 39 +/- 15 l/h in the control subjects (p less than 0.05) and from 15 +/- 6 l/h to 21 +/- 7 l/h in the cirrhosis patients (p less than 0.05). ...
This increased the hepatic nitrogen clearance from 27 +/- 10 l/h to 39 +/- 15 l/h in the control subjects (p less than 0.05) a …
Effects of epinephrine on urea synthesis in vivo in rats.
Heindorff H, Almdal T, Vilstrup H. Heindorff H, et al. Liver. 1992 Feb;12(1):46-9. doi: 10.1111/j.1600-0676.1992.tb00554.x. Liver. 1992. PMID: 1564985
The effect of exogenous epinephrine on the rate of urea synthesis was studied in rats receiving epinephrine at rates of 2 and 20 micrograms/kg/h. ...
The effect of exogenous epinephrine on the rate of urea synthesis was studied in rats receiving epinephrine at rates of 2 and 20 micrograms/ …
Glucagon immunoneutralization in diabetic rats normalizes urea synthesis and decreases nitrogen wasting.
Almdal TP, Holst JJ, Heindorff H, Vilstrup H. Almdal TP, et al. Diabetes. 1992 Jan;41(1):12-6. doi: 10.2337/diab.41.1.12. Diabetes. 1992. PMID: 1727732
In control rats, the accumulated nitrogen balance, determined weekly for 4 wk, was positive at 81 +/- 3.1 mmol/96 h; in serum-treated diabetic rats, the accumulated nitrogen balance was negative, -8.3 +/- 2.4 mmol/96 h throughout the 4 wk, whereas it was higher at 4 …
In control rats, the accumulated nitrogen balance, determined weekly for 4 wk, was positive at 81 +/- 3.1 mmol/96 h; in serum-treated …
Blockade of glucocorticoid receptors prevents the increase in urea synthesis after hysterectomy in rats.
Heindorff H, Almdal TP, Vilstrup H. Heindorff H, et al. Eur J Clin Invest. 1991 Dec;21(6):625-30. doi: 10.1111/j.1365-2362.1991.tb01419.x. Eur J Clin Invest. 1991. PMID: 1778224
Hysterectomy doubled UNSR from 3.16 +/- 0.20 to 6.12 +/- 0.27 mumol (per min per 100 g body weight) after 3 h (P less than 0.01) and increased CUNS by 40% from 7.47 +/- 0.30 to 10.29 +/- 0.41 mumol (per min per 100 g body weight) after 24 h (P less than 0.01). ...Hy …
Hysterectomy doubled UNSR from 3.16 +/- 0.20 to 6.12 +/- 0.27 mumol (per min per 100 g body weight) after 3 h (P less than 0.01) and …
Effect of dietary protein on the capacity of urea synthesis in rats.
Petersen KF, Vilstrup H, Tygstrup N. Petersen KF, et al. Horm Metab Res. 1990 Dec;22(12):612-5. doi: 10.1055/s-2007-1004985. Horm Metab Res. 1990. PMID: 2076858
Increased hepatic efficacy of urea synthesis from alanine in insulin-dependent diabetes mellitus.
Almdal TP, Jensen T, Vilstrup H. Almdal TP, et al. Eur J Clin Invest. 1990 Feb;20(1):29-34. doi: 10.1111/j.1365-2362.1990.tb01787.x. Eur J Clin Invest. 1990. PMID: 2108034
Following an overnight fast alanine was infused at 2 mmol h-1 kg-1 body weight. The hourly rate of urea synthesis was determined as the urinary excretion of urea corrected for accumulation of urea in total body water and intestinal hydrolysis. ...The functional hepatic nit …
Following an overnight fast alanine was infused at 2 mmol h-1 kg-1 body weight. The hourly rate of urea synthesis was determined as t …
No effect of bicarbonate-induced alkalosis on urea synthesis in normal man.
Bjerrum K, Vilstrup H, Almdal TP, Ostergaard Kristensen L. Bjerrum K, et al. Scand J Clin Lab Invest. 1990 Apr;50(2):137-41. doi: 10.1080/00365519009089145. Scand J Clin Lab Invest. 1990. PMID: 2160122
Infusion of bicarbonate (115 mmol/h) increased pH of the venous blood by 0.10 units. In four subjects fasting urea synthesis was 24 mmol N/h at normal pH and unaffected by alkalosis (mean difference +/- SED was 1.04 +/- 4.1). In six subjects alanine was infused so a …
Infusion of bicarbonate (115 mmol/h) increased pH of the venous blood by 0.10 units. In four subjects fasting urea synthesis was 24 m …
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