Bilateral Breast Radiation Associated Angiosarcoma After Radiotherapy for Bilateral Invasive Ductal Adenocarcinoma

Guy Vin Chang; Chencheng Xie; Mahum Shahid; Jillian Draine; Josie Alpers; Bailey Reindl; Michael McHale

Bilateral Breast Radiation Associated Angiosarcoma After Radiotherapy for Bilateral Invasive Ductal Adenocarcinoma

S D Med. 2021 Jun;74(6):260-263.

Authors

Guy Vin Chang¹, Chencheng Xie¹, Mahum Shahid¹, Jillian Draine¹, Josie Alpers¹, Bailey Reindl², Michael McHale¹

Affiliations

¹ Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.
² University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

PMID: 34449165

Abstract

Angiosarcoma is a rare, highly malignant endothelial cell carcinoma. Radiotherapy on breast cancer increases the risk of developing an angiosarcoma. We report an extremely rare case of bilateral breast radiation-associated angiosarcoma (RAA). Patient had a strong breast cancer family history, and genetic testing identified KRAS, PIK3CA, RPTOR, and VHL mutation, along with MYC amplification. The overall prognosis of RAA is poor as RAA is characterized by early metastasis, frequent local recurrence, and short overall survival time. The patient eventually passed away because of breast cancer metastasis to the lung and liver.

Publication types

Case Reports

MeSH terms

Adenocarcinoma*
Breast Neoplasms* / radiotherapy
Female
Hemangiosarcoma* / etiology
Humans
Prognosis