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408 results

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Page 1
Vincristine sulfate liposome injection: a guide to its use in refractory or relapsed acute lymphoblastic leukemia.
Harrison TS, Lyseng-Williamson KA. Harrison TS, et al. BioDrugs. 2013 Feb;27(1):69-74. doi: 10.1007/s40259-012-0002-5. BioDrugs. 2013. PMID: 23329395 Review.
Adult patients with acute lymphoblastic leukemia frequently relapse or are refractory to conventional treatments. The vincristine sulfate liposome injection (Marqibo()) encapsulates the drug in a liposome composed of sphingomyelin and cholesterol to im …
Adult patients with acute lymphoblastic leukemia frequently relapse or are refractory to conventional treatments. The vincristine …
Vincristine Sulfate Liposome Injection with Bendamustine and Rituximab as First-Line Therapy for B-Cell Lymphomas: A Phase I Study.
Ollila T, Butera J, Egan P, Reagan J, Thomas A, Yakirevich I, MacKinnon K, Margolis J, McMahon J, Rosati V, Olszewski AJ. Ollila T, et al. Oncologist. 2022 Jul 5;27(7):532-e542. doi: 10.1093/oncolo/oyab079. Oncologist. 2022. PMID: 35641232 Free PMC article. Clinical Trial.
BACKGROUND: We conducted an investigator-initiated, phase I trial of vincristine sulfate liposomal injection (VSLI) in combination with bendamustine and rituximab (BR) for indolent B-cell (BCL) or mantle cell lymphoma. ...Maximum tolerated dose (MTD) was the …
BACKGROUND: We conducted an investigator-initiated, phase I trial of vincristine sulfate liposomal injection (VSLI) in …
Marqibo (vincristine sulfate liposome injection) improves the pharmacokinetics and pharmacodynamics of vincristine.
Silverman JA, Deitcher SR. Silverman JA, et al. Cancer Chemother Pharmacol. 2013 Mar;71(3):555-64. doi: 10.1007/s00280-012-2042-4. Epub 2012 Dec 5. Cancer Chemother Pharmacol. 2013. PMID: 23212117 Free PMC article. Review.
Vincristine (VCR) is a mainstay of treatment of hematologic malignancies and solid tumors due to its well-defined mechanism of action, demonstrated anticancer activity and its ability to be combined with other agents. ...These properties may limit optimal drug exposure and …
Vincristine (VCR) is a mainstay of treatment of hematologic malignancies and solid tumors due to its well-defined mechanism of action …
Efficacy and Safety of Vincristine Sulfate Liposome Injection in the Treatment of Adult Acute Lymphocytic Leukemia.
Douer D. Douer D. Oncologist. 2016 Jul;21(7):840-7. doi: 10.1634/theoncologist.2015-0391. Epub 2016 Jun 21. Oncologist. 2016. PMID: 27328933 Free PMC article. Review.
Vincristine sulfate liposome injection (VSLI) is a sphingomyelin/cholesterol-based liposome-encapsulated formulation that is delivered weekly in a 1-hour infusion. ...IMPLICATIONS FOR PRACTICE: This review summarizes the development of vincristine …
Vincristine sulfate liposome injection (VSLI) is a sphingomyelin/cholesterol-based liposome-encapsulated formula …
Vincristine Sulfate Liposome Injection With Combination Chemotherapy for Children, Adolescents, and Young Adults With Relapsed Acute Lymphoblastic Leukemia: A Therapeutic Advances in Childhood Leukemia and Lymphoma Consortium Trial.
Shah NN, Schafer ES, Chi YY, Malvar J, Heym KM, Place AE, Burns M, Chang BH, Slone T, Verma A, Gossai N, Shaw PH, Burke MJ, Hermiston M, Schore RJ, Cooper T, Pauly M, Rushing T, Jarosinski P, Florendo E, Yates B, Widemann BC, Peer CJ, Figg WD, Silverman LB, Bhojwani D, Wayne AS. Shah NN, et al. Pediatr Blood Cancer. 2025 May;72(5):e31584. doi: 10.1002/pbc.31584. Epub 2025 Feb 12. Pediatr Blood Cancer. 2025. PMID: 39937083 Free PMC article.
INTRODUCTION: Vincristine sulfate liposome injection (VSLI), a liposomal formulation of vincristine, may be better tolerated than standard aqueous vincristine and enable dose intensification. ...Collectively, the median VSLI dose administ …
INTRODUCTION: Vincristine sulfate liposome injection (VSLI), a liposomal formulation of vincristine, may …
Investigational chemotherapy and novel pharmacokinetic mechanisms for the treatment of breast cancer brain metastases.
Shah N, Mohammad AS, Saralkar P, Sprowls SA, Vickers SD, John D, Tallman RM, Lucke-Wold BP, Jarrell KE, Pinti M, Nolan RL, Lockman PR. Shah N, et al. Pharmacol Res. 2018 Jun;132:47-68. doi: 10.1016/j.phrs.2018.03.021. Epub 2018 Mar 28. Pharmacol Res. 2018. PMID: 29604436 Free PMC article. Review.
The mechanisms of novel dosage formulations such as nanoparticles, liposomes, pegylation, the concepts of enhanced permeation and retention, and drugs utilizing these concepts involved in clinical trials are also discussed. ...
The mechanisms of novel dosage formulations such as nanoparticles, liposomes, pegylation, the concepts of enhanced permeation and ret …
Pharmacokinetic Behavior of Vincristine and Safety Following Intravenous Administration of Vincristine Sulfate Liposome Injection in Chinese Patients With Malignant Lymphoma.
Yang F, Jiang M, Lu M, Hu P, Wang H, Jiang J. Yang F, et al. Front Pharmacol. 2018 Aug 29;9:991. doi: 10.3389/fphar.2018.00991. eCollection 2018. Front Pharmacol. 2018. PMID: 30210349 Free PMC article.
Objective: This phase Ia study was designed to assess the pharmacokinetic (PK) characters of free vincristine (F-VCR, refer to as non-liposomal VCR and VCR released from liposome) and total vincristine (T-VCR, the sum of both liposomal VCR and F …
Objective: This phase Ia study was designed to assess the pharmacokinetic (PK) characters of free vincristine (F-VCR, refer to as non …
High-Dose Vincristine Sulfate Liposome Injection, for Advanced, Relapsed, or Refractory Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia in an Adolescent and Young Adult Subgroup of a Phase 2 Clinical Trial.
Schiller GJ, Damon LE, Coutre SE, Hsu P, Bhat G, Douer D. Schiller GJ, et al. J Adolesc Young Adult Oncol. 2018 Oct;7(5):546-552. doi: 10.1089/jayao.2018.0041. Epub 2018 Sep 21. J Adolesc Young Adult Oncol. 2018. PMID: 30239252 Clinical Trial.
PURPOSE: A study of vincristine sulfate (VCR) liposome injection (VSLI) was conducted in patients with advanced, relapsed, or refractory, Philadelphia chromosome-negative acute lymphoblastic/lymphocytic leukemia (ALL). ...
PURPOSE: A study of vincristine sulfate (VCR) liposome injection (VSLI) was conducted in patients with advanced, relaps …
Vincristine sulfate liposomal injection for acute lymphoblastic leukemia.
Raj TA, Smith AM, Moore AS. Raj TA, et al. Int J Nanomedicine. 2013;8:4361-9. doi: 10.2147/IJN.S54657. Epub 2013 Nov 6. Int J Nanomedicine. 2013. PMID: 24232122 Free PMC article. Review.
Vincristine (VCR) is one of the most extensively used cytotoxic compounds in hemato-oncology. ...In the last decade, however, the discovery that liposomal encapsulation of chemotherapeutics can modulate the pharmacokinetic characteristics of a compound has stimulate …
Vincristine (VCR) is one of the most extensively used cytotoxic compounds in hemato-oncology. ...In the last decade, however, the dis …
A pilot study with vincristine sulfate liposome infusion in patients with metastatic melanoma.
Bedikian AY, Papadopoulos NE, Kim KB, Vardeleon A, Smith T, Lu B, Deitcher SR. Bedikian AY, et al. Melanoma Res. 2008 Dec;18(6):400-4. doi: 10.1097/CMR.0b013e328311aaa1. Melanoma Res. 2008. PMID: 19011511 Clinical Trial.
Vincristine sulfate liposome infusion (VSLI) is a sphingomyelin/cholesterol liposome encapsulated formulation of vincristine that results in an extended drug circulation time and the potential for enhanced malignancy targeting, exposure, and ant …
Vincristine sulfate liposome infusion (VSLI) is a sphingomyelin/cholesterol liposome encapsulated formulation of …
408 results