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Nucleases Acting at Stalled Forks: How to Reboot the Replication Program with a Few Shortcuts.

Pasero P, Vindigni A. Pasero P, et al. Among authors: vindigni a. Annu Rev Genet. 2017 Nov 27;51:477-499. doi: 10.1146/annurev-genet-120116-024745. Annu Rev Genet. 2017. PMID: 29178820 Review.

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Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures.

Pike AC, Gomathinayagam S, Swuec P, Berti M, Zhang Y, Schnecke C, Marino F, von Delft F, Renault L, Costa A, Gileadi O, Vindigni A. Pike AC, et al. Among authors: vindigni a. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4286-91. doi: 10.1073/pnas.1417594112. Epub 2015 Mar 23. Proc Natl Acad Sci U S A. 2015. PMID: 25831490 Free PMC article.

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Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition.

Berti M, Ray Chaudhuri A, Thangavel S, Gomathinayagam S, Kenig S, Vujanovic M, Odreman F, Glatter T, Graziano S, Mendoza-Maldonado R, Marino F, Lucic B, Biasin V, Gstaiger M, Aebersold R, Sidorova JM, Monnat RJ Jr, Lopes M, Vindigni A. Berti M, et al. Among authors: vindigni a. Nat Struct Mol Biol. 2013 Mar;20(3):347-54. doi: 10.1038/nsmb.2501. Epub 2013 Feb 10. Nat Struct Mol Biol. 2013. PMID: 23396353 Free PMC article.

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Human ribonuclease H1 resolves R-loops and thereby enables progression of the DNA replication fork.

Parajuli S, Teasley DC, Murali B, Jackson J, Vindigni A, Stewart SA. Parajuli S, et al. Among authors: vindigni a. J Biol Chem. 2017 Sep 15;292(37):15216-15224. doi: 10.1074/jbc.M117.787473. Epub 2017 Jul 17. J Biol Chem. 2017. PMID: 28717002 Free PMC article.

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Special issue: "At the Intersection of DNA Replication and Genome Maintenance: from Mechanisms to Therapy".

Vindigni A. Vindigni A. Biophys Chem. 2017 Jun;225:1-2. doi: 10.1016/j.bpc.2017.04.007. Biophys Chem. 2017. PMID: 28641746 No abstract available.

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DNA2 drives processing and restart of reversed replication forks in human cells.

Thangavel S, Berti M, Levikova M, Pinto C, Gomathinayagam S, Vujanovic M, Zellweger R, Moore H, Lee EH, Hendrickson EA, Cejka P, Stewart S, Lopes M, Vindigni A. Thangavel S, et al. Among authors: vindigni a. J Cell Biol. 2015 Mar 2;208(5):545-62. doi: 10.1083/jcb.201406100. J Cell Biol. 2015. PMID: 25733713 Free PMC article.

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The two faces of DNA repair: disease and therapy.

Vindigni A, Gonzalo S. Vindigni A, et al. Mo Med. 2013 Jul-Aug;110(4):314-9. Mo Med. 2013. PMID: 24003649 Free PMC article.

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Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors.

Yamamoto K, Wang J, Sprinzen L, Xu J, Haddock CJ, Li C, Lee BJ, Loredan DG, Jiang W, Vindigni A, Wang D, Rabadan R, Zha S. Yamamoto K, et al. Among authors: vindigni a. Elife. 2016 Jun 15;5:e14709. doi: 10.7554/eLife.14709. Elife. 2016. PMID: 27304073 Free PMC article.

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XLF and H2AX function in series to promote replication fork stability.

Chen BR, Quinet A, Byrum AK, Jackson J, Berti M, Thangavel S, Bredemeyer AL, Hindi I, Mosammaparast N, Tyler JK, Vindigni A, Sleckman BP. Chen BR, et al. Among authors: vindigni a. J Cell Biol. 2019 Jul 1;218(7):2113-2123. doi: 10.1083/jcb.201808134. Epub 2019 May 23. J Cell Biol. 2019. PMID: 31123184 Free PMC article.

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Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function.

Byrum AK, Carvajal-Maldonado D, Mudge MC, Valle-Garcia D, Majid MC, Patel R, Sowa ME, Gygi SP, Harper JW, Shi Y, Vindigni A, Mosammaparast N. Byrum AK, et al. Among authors: vindigni a. J Cell Biol. 2019 Feb 4;218(2):422-432. doi: 10.1083/jcb.201803003. Epub 2019 Jan 2. J Cell Biol. 2019. PMID: 30602538 Free PMC article.

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