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A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.
Vinuesa CG, Cook MC, Angelucci C, Athanasopoulos V, Rui L, Hill KM, Yu D, Domaschenz H, Whittle B, Lambe T, Roberts IS, Copley RR, Bell JI, Cornall RJ, Goodnow CC. Vinuesa CG, et al. Nature. 2005 May 26;435(7041):452-8. doi: 10.1038/nature03555. Nature. 2005. PMID: 15917799
Cellular and genetic mechanisms of self tolerance and autoimmunity.
Goodnow CC, Sprent J, Fazekas de St Groth B, Vinuesa CG. Goodnow CC, et al. Nature. 2005 Jun 2;435(7042):590-7. doi: 10.1038/nature03724. Nature. 2005. PMID: 15931211 Review.
Follicular B helper T cells in antibody responses and autoimmunity.
Vinuesa CG, Tangye SG, Moser B, Mackay CR. Vinuesa CG, et al. Nat Rev Immunol. 2005 Nov;5(11):853-65. doi: 10.1038/nri1714. Nat Rev Immunol. 2005. PMID: 16261173 Review.
Axon growth and guidance genes identify T-dependent germinal centre B cells.
Yu D, Cook MC, Shin DM, Silva DG, Marshall J, Toellner KM, Havran WL, Caroni P, Cooke MP, Morse HC, MacLennan IC, Goodnow CC, Vinuesa CG. Yu D, et al. Immunol Cell Biol. 2008 Jan;86(1):3-14. doi: 10.1038/sj.icb.7100123. Epub 2007 Oct 16. Immunol Cell Biol. 2008. PMID: 17938642
Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA.
Yu D, Tan AH, Hu X, Athanasopoulos V, Simpson N, Silva DG, Hutloff A, Giles KM, Leedman PJ, Lam KP, Goodnow CC, Vinuesa CG. Yu D, et al. Nature. 2007 Nov 8;450(7167):299-303. doi: 10.1038/nature06253. Nature. 2007. PMID: 18172933
Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS.
Linterman MA, Rigby RJ, Wong R, Silva D, Withers D, Anderson G, Verma NK, Brink R, Hutloff A, Goodnow CC, Vinuesa CG. Linterman MA, et al. Immunity. 2009 Feb 20;30(2):228-41. doi: 10.1016/j.immuni.2008.12.015. Epub 2009 Feb 12. Immunity. 2009. PMID: 19217324
Follicular helper T cells are required for systemic autoimmunity.
Linterman MA, Rigby RJ, Wong RK, Yu D, Brink R, Cannons JL, Schwartzberg PL, Cook MC, Walters GD, Vinuesa CG. Linterman MA, et al. J Exp Med. 2009 Mar 16;206(3):561-76. doi: 10.1084/jem.20081886. Epub 2009 Feb 16. J Exp Med. 2009. PMID: 19221396 Free PMC article.
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