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Distinct kinetics of cytokine production and cytolysis in effector and memory T cells after viral infection.
Bachmann MF, Barner M, Viola A, Kopf M. Bachmann MF, et al. Eur J Immunol. 1999 Jan;29(1):291-9. doi: 10.1002/(SICI)1521-4141(199901)29:01<291::AID-IMMU291>3.0.CO;2-K. Eur J Immunol. 1999. PMID: 9933111
Our results show that memory T cells exhibit a unique phenotype in that they produce cytokines and commit to proliferation as rapidly as effector cells, whereas they resemble naive T cells in the time requirement for development of cytolytic function....
Our results show that memory T cells exhibit a unique phenotype in that they produce cytokines and commit to proliferation as rapidly …
Modulation of human T-cell functions by reactive nitrogen species.
Kasic T, Colombo P, Soldani C, Wang CM, Miranda E, Roncalli M, Bronte V, Viola A. Kasic T, et al. Eur J Immunol. 2011 Jul;41(7):1843-9. doi: 10.1002/eji.201040868. Epub 2011 Jun 7. Eur J Immunol. 2011. PMID: 21480210
In this manuscript, we explored this hypothesis and provided a direct demonstration of the inhibitory effects of RNS on human T-cell signaling, activation, and migration. ...Since substantial protein nitration, a hallmark of nitrative stress, was observed in various …
In this manuscript, we explored this hypothesis and provided a direct demonstration of the inhibitory effects of RNS on human T-cell …
Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1.
Marinari B, Costanzo A, Viola A, Michel F, Mangino G, Acuto O, Levrero M, Piccolella E, Tuosto L. Marinari B, et al. Eur J Immunol. 2002 Feb;32(2):447-56. doi: 10.1002/1521-4141(200202)32:2<447::AID-IMMU447>3.0.CO;2-5. Eur J Immunol. 2002. PMID: 11813163
We have recently demonstrated that the mitogen-activated kinase kinase 1 (MEKK1), a kinase known to regulate the c-jun N-terminal kinase (JNK) pathway, is also involved in the CD28- and TCR-induced inhibitor of kappaB factor (IkappaB) kinases (IKK) and NF-kappaB activation …
We have recently demonstrated that the mitogen-activated kinase kinase 1 (MEKK1), a kinase known to regulate the c-jun N-terminal kin …
Lipid rafts and T cell receptor signaling: a critical re-evaluation.
Pizzo P, Giurisato E, Tassi M, Benedetti A, Pozzan T, Viola A. Pizzo P, et al. Eur J Immunol. 2002 Nov;32(11):3082-91. doi: 10.1002/1521-4141(200211)32:11<3082::AID-IMMU3082>3.0.CO;2-2. Eur J Immunol. 2002. PMID: 12385028
Indeed, we found that the reported inhibition of TCR-induced Ca2+ influx by M beta CD treatment is mainly due to (a) nonspecific depletion of intracellular Ca2+ stores and (b) plasma membrane depolarization of T cells. ...
Indeed, we found that the reported inhibition of TCR-induced Ca2+ influx by M beta CD treatment is mainly due to (a) nonspecific depl …
T-cell activation and the dynamic world of rafts.
Viola A, Lanzavecchia A. Viola A, et al. APMIS. 1999 Jul;107(7):615-23. doi: 10.1111/j.1699-0463.1999.tb01450.x. APMIS. 1999. PMID: 10440056 Review.
In addition to the interaction between the TCR molecule and its ligand, T-cell activation depends on a combination of many other events involving coreceptor molecules, actin cytoskeleton and plasma membrane lipids. Altogether, these cell structures organize the formation o …
In addition to the interaction between the TCR molecule and its ligand, T-cell activation depends on a combination of many other even …
Developmental regulation of Lck targeting to the CD8 coreceptor controls signaling in naive and memory T cells.
Bachmann MF, Gallimore A, Linkert S, Cerundolo V, Lanzavecchia A, Kopf M, Viola A. Bachmann MF, et al. J Exp Med. 1999 May 17;189(10):1521-30. doi: 10.1084/jem.189.10.1521. J Exp Med. 1999. PMID: 10330431 Free PMC article.
We found that memory T cells are qualitatively different from naive T cells due to a developmentally regulated rearrangement of the topology of the signaling machinery. In naive cytotoxic T cells, only a few CD8 molecules are associated with Lck and the kinase is ho …
We found that memory T cells are qualitatively different from naive T cells due to a developmentally regulated rearrangement of the t …
From TCR engagement to T cell activation: a kinetic view of T cell behavior.
Lanzavecchia A, Iezzi G, Viola A. Lanzavecchia A, et al. Cell. 1999 Jan 8;96(1):1-4. doi: 10.1016/s0092-8674(00)80952-6. Cell. 1999. PMID: 9989490 Review. No abstract available.
T lymphocyte costimulation mediated by reorganization of membrane microdomains.
Viola A, Schroeder S, Sakakibara Y, Lanzavecchia A. Viola A, et al. Science. 1999 Jan 29;283(5402):680-2. doi: 10.1126/science.283.5402.680. Science. 1999. PMID: 9924026
These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains....
These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains....
A T cell receptor (TCR) antagonist competitively inhibits serial TCR triggering by low-affinity ligands, but does not affect triggering by high-affinity anti-CD3 antibodies.
Viola A, Linkert S, Lanzavecchia A. Viola A, et al. Eur J Immunol. 1997 Nov;27(11):3080-3. doi: 10.1002/eji.1830271146. Eur J Immunol. 1997. PMID: 9394839
We report that a TCR antagonist competitively inhibits TCR triggering induced by low-affinity ligands such as agonistic peptides or bacterial superantigens. ...
We report that a TCR antagonist competitively inhibits TCR triggering induced by low-affinity ligands such as agonistic peptides or b …
T cell activation determined by T cell receptor number and tunable thresholds.
Viola A, Lanzavecchia A. Viola A, et al. Science. 1996 Jul 5;273(5271):104-6. doi: 10.1126/science.273.5271.104. Science. 1996. PMID: 8658175
A unitary requirement for T cell responses was revealed by measurement of the number of triggered TCRs. Irrespective of the nature of the triggering ligand, T cells "counted" the number of triggered TCRs and responded when a threshold of approximately 8000 TCRs was
A unitary requirement for T cell responses was revealed by measurement of the number of triggered TCRs. Irrespective of the nature of
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