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Effects of acute GR38032F (odansetron), a 5-HT3 receptor antagonist, on dopamine and serotonin metabolism in mesolimbic and nigrostriatal dopaminergic neurons.
Koulu M, Sjöholm B, Lappalainen J, Virtanen R. Koulu M, et al. Among authors: virtanen r. Eur J Pharmacol. 1989 Oct 10;169(2-3):321-4. doi: 10.1016/0014-2999(89)90031-9. Eur J Pharmacol. 1989. PMID: 2530097
Pharmacological characterisation of a structurally novel α2C-adrenoceptor antagonist ORM-10921 and its effects in neuropsychiatric models.
Sallinen J, Holappa J, Koivisto A, Kuokkanen K, Chapman H, Lehtimäki J, Piepponen P, Mijatovic J, Tanila H, Virtanen R, Sirviö J, Haapalinna A. Sallinen J, et al. Among authors: virtanen r. Basic Clin Pharmacol Toxicol. 2013 Oct;113(4):239-49. doi: 10.1111/bcpt.12090. Epub 2013 Jun 20. Basic Clin Pharmacol Toxicol. 2013. PMID: 23718812
Pharmacological profile of intrathecal fadolmidine, a alpha2-adrenoceptor agonist, in rodent models.
Leino T, Viitamaa T, Haapalinna A, Lehtimäki J, Virtanen R. Leino T, et al. Among authors: virtanen r. Naunyn Schmiedebergs Arch Pharmacol. 2009 Dec;380(6):539-50. doi: 10.1007/s00210-009-0460-6. Epub 2009 Oct 14. Naunyn Schmiedebergs Arch Pharmacol. 2009. PMID: 19826791
In vitro and in vivo profiling of fadolmidine, a novel potent alpha(2)-adrenoceptor agonist with local mode of action.
Lehtimäki J, Leino T, Koivisto A, Viitamaa T, Lehtimäki T, Haapalinna A, Kuokkanen K, Virtanen R. Lehtimäki J, et al. Among authors: virtanen r. Eur J Pharmacol. 2008 Dec 3;599(1-3):65-71. doi: 10.1016/j.ejphar.2008.10.003. Epub 2008 Oct 9. Eur J Pharmacol. 2008. PMID: 18930723
Evaluation of the alpha 1- and alpha 2-adrenoceptor effects of detomidine, a novel veterinary sedative analgesic.
Virtanen R, Nyman L. Virtanen R, et al. Eur J Pharmacol. 1985 Jan 22;108(2):163-9. doi: 10.1016/0014-2999(85)90721-6. Eur J Pharmacol. 1985. PMID: 2984021
alpha 2-Adrenoceptor agonists decrease free 3-methoxy-4-hydroxyphenylglycol in rat cerebrospinal fluid.
Scheinin H, Virtanen R, Scheinin M. Scheinin H, et al. Among authors: virtanen r. Eur J Pharmacol. 1986 Apr 9;123(1):115-21. doi: 10.1016/0014-2999(86)90695-3. Eur J Pharmacol. 1986. PMID: 2872072
The effects of a specific alpha(2)-adrenoceptor antagonist, atipamezole, on cognitive performance and brain neurochemistry in aged Fisher 344 rats.
Haapalinna A, Sirviö J, MacDonald E, Virtanen R, Heinonen E. Haapalinna A, et al. Among authors: virtanen r. Eur J Pharmacol. 2000 Jan 10;387(2):141-50. doi: 10.1016/s0014-2999(99)00819-5. Eur J Pharmacol. 2000. PMID: 10650154
Comparison of the effects of acute and subchronic administration of atipamezole on reaction to novelty and active avoidance learning in rats.
Haapalinna A, MacDonald E, Viitamaa T, Salonen JS, Sirviö J, Virtanen R. Haapalinna A, et al. Among authors: virtanen r. Naunyn Schmiedebergs Arch Pharmacol. 1999 Mar;359(3):194-203. doi: 10.1007/pl00005342. Naunyn Schmiedebergs Arch Pharmacol. 1999. PMID: 10208306
Protean agonism at alpha2A-adrenoceptors.
Jansson CC, Kukkonen JP, Näsman J, Huifang G, Wurster S, Virtanen R, Savola JM, Cockcroft V, Akerman KE. Jansson CC, et al. Among authors: virtanen r. Mol Pharmacol. 1998 May;53(5):963-8. Mol Pharmacol. 1998. PMID: 9584224
Evaluation of the effects of a specific alpha 2-adrenoceptor antagonist, atipamezole, on alpha 1- and alpha 2-adrenoceptor subtype binding, brain neurochemistry and behaviour in comparison with yohimbine.
Haapalinna A, Viitamaa T, MacDonald E, Savola JM, Tuomisto L, Virtanen R, Heinonen E. Haapalinna A, et al. Among authors: virtanen r. Naunyn Schmiedebergs Arch Pharmacol. 1997 Nov;356(5):570-82. doi: 10.1007/pl00005092. Naunyn Schmiedebergs Arch Pharmacol. 1997. PMID: 9402036
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