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The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma2 isoform.
Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppänen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A. Medina-Gomez G, et al. Among authors: virtue s. Diabetes. 2005 Jun;54(6):1706-16. doi: 10.2337/diabetes.54.6.1706. Diabetes. 2005. PMID: 15919792 Free PMC article.
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.
Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. Medina-Gomez G, et al. Among authors: virtue s. PLoS Genet. 2007 Apr 27;3(4):e64. doi: 10.1371/journal.pgen.0030064. PLoS Genet. 2007. PMID: 17465682 Free PMC article.
It's not how fat you are, it's what you do with it that counts.
Virtue S, Vidal-Puig A. Virtue S, et al. PLoS Biol. 2008 Sep 23;6(9):e237. doi: 10.1371/journal.pbio.0060237. PLoS Biol. 2008. PMID: 18816166 Free PMC article.
Mechanisms underlying obesity-related metabolic disorders are poorly understood. Samuel Virtue and Antonio Vidal-Puig explore the evidence for an emerging hypothesis that attributes metabolic complications not to obesity per se, but to an individual's capacity for a …
Mechanisms underlying obesity-related metabolic disorders are poorly understood. Samuel Virtue and Antonio Vidal-Puig explore the evi …
Metabolic phenotyping of a model of adipocyte differentiation.
Roberts LD, Virtue S, Vidal-Puig A, Nicholls AW, Griffin JL. Roberts LD, et al. Among authors: virtue s. Physiol Genomics. 2009 Oct 7;39(2):109-19. doi: 10.1152/physiolgenomics.90365.2008. Epub 2009 Jul 14. Physiol Genomics. 2009. PMID: 19602617 Free PMC article.
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