Visintin A - Search Results

1

A coding mutation within the first exon of the human MD-2 gene results in decreased lipopolysaccharide-induced signaling.

Hamann L, Kumpf O, Müller M, Visintin A, Eckert J, Schlag PM, Schumann RR. Hamann L, et al. Among authors: visintin a. Genes Immun. 2004 Jun;5(4):283-8. doi: 10.1038/sj.gene.6364068. Genes Immun. 2004. PMID: 15057266

2

MD-2.

Visintin A, Iliev DB, Monks BG, Halmen KA, Golenbock DT. Visintin A, et al. Immunobiology. 2006;211(6-8):437-47. doi: 10.1016/j.imbio.2006.05.010. Epub 2006 Jul 18. Immunobiology. 2006. PMID: 16920483 Review.

3

Inhibition of TLR-4/MD-2 signaling by RP105/MD-1.

Divanovic S, Trompette A, Atabani SF, Madan R, Golenbock DT, Visintin A, Finberg RW, Tarakhovsky A, Vogel SN, Belkaid Y, Kurt-Jones EA, Karp CL. Divanovic S, et al. Among authors: visintin a. J Endotoxin Res. 2005;11(6):363-8. doi: 10.1179/096805105X67300. J Endotoxin Res. 2005. PMID: 16303092

4

Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4.

Visintin A, Mazzoni A, Spitzer JA, Segal DM. Visintin A, et al. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12156-61. doi: 10.1073/pnas.211445098. Epub 2001 Oct 2. Proc Natl Acad Sci U S A. 2001. PMID: 11593030 Free PMC article.

5

Trypsin-sensitive modulation of intestinal epithelial MD-2 as mechanism of lipopolysaccharide tolerance.

Cario E, Golenbock DT, Visintin A, Rünzi M, Gerken G, Podolsky DK. Cario E, et al. Among authors: visintin a. J Immunol. 2006 Apr 1;176(7):4258-66. doi: 10.4049/jimmunol.176.7.4258. J Immunol. 2006. PMID: 16547263

6

Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction.

Visintin A, Latz E, Monks BG, Espevik T, Golenbock DT. Visintin A, et al. J Biol Chem. 2003 Nov 28;278(48):48313-20. doi: 10.1074/jbc.M306802200. Epub 2003 Sep 5. J Biol Chem. 2003. PMID: 12960171 Free article.

7

Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells.

Spitzer JH, Visintin A, Mazzoni A, Kennedy MN, Segal DM. Spitzer JH, et al. Among authors: visintin a. Eur J Immunol. 2002 Apr;32(4):1182-7. doi: 10.1002/1521-4141(200204)32:4<1182::AID-IMMU1182>3.0.CO;2-9. Eur J Immunol. 2002. PMID: 11932926 Free article.

8

Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling.

Jain V, Halle A, Halmen KA, Lien E, Charrel-Dennis M, Ram S, Golenbock DT, Visintin A. Jain V, et al. Among authors: visintin a. Blood. 2008 May 1;111(9):4637-45. doi: 10.1182/blood-2007-11-126862. Epub 2008 Jan 18. Blood. 2008. PMID: 18203953 Free PMC article.

9

Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction.

Latz E, Visintin A, Lien E, Fitzgerald KA, Monks BG, Kurt-Jones EA, Golenbock DT, Espevik T. Latz E, et al. Among authors: visintin a. J Biol Chem. 2002 Dec 6;277(49):47834-43. doi: 10.1074/jbc.M207873200. Epub 2002 Sep 24. J Biol Chem. 2002. PMID: 12324469 Free article.

10

The role of disulfide bonds in the assembly and function of MD-2.

Mullen GE, Kennedy MN, Visintin A, Mazzoni A, Leifer CA, Davies DR, Segal DM. Mullen GE, et al. Among authors: visintin a. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3919-24. doi: 10.1073/pnas.0630495100. Epub 2003 Mar 17. Proc Natl Acad Sci U S A. 2003. PMID: 12642668 Free PMC article.

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