Visualization of AMPA receptors in living human brain with positron emission tomography.
Nat Med. 2020.
PMID: 31959988
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Visualization of AMPA receptors in living human brain with positron emission tomography.
Miyazaki T, Nakajima W, Hatano M, Shibata Y, Kuroki Y, Arisawa T, Serizawa A, Sano A, Kogami S, Yamanoue T, Kimura K, Hirata Y, Takada Y, Ishiwata Y, Sonoda M, Tokunaga M, Seki C, Nagai Y, Minamimoto T, Kawamura K, Zhang MR, Ikegaya N, Iwasaki M, Kunii N, Kimura Y, Yamashita F, Taguri M, Tani H, Nagai N, Koizumi T, Nakajima S, Mimura M, Yuzaki M, Kato H, Higuchi M, Uchida H, Takahashi T.
Miyazaki T, et al.
Nat Med. 2020 Feb;26(2):281-288. doi: 10.1038/s41591-019-0723-9. Epub 2020 Jan 20.
Nat Med. 2020.
PMID: 31959988
Although aberrations in the number and function of glutamate AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors are thought to underlie neuropsychiatric disorders, no methods are currently available for visualizing AMPA recep …
Although aberrations in the number and function of glutamate AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) rece …
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[(11)C]K-2 image with positron emission tomography represents cell surface AMPA receptors.
Arisawa T, Miyazaki T, Ota W, Sano A, Suyama K, Takada Y, Takahashi T.
Arisawa T, et al.
Neurosci Res. 2021 Dec;173:106-113. doi: 10.1016/j.neures.2021.05.009. Epub 2021 May 24.
Neurosci Res. 2021.
PMID: 34033829
Free article.
The glutamate alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) is an important molecule in neurotransmission. We have recently developed the first positron emission tomography (PET) tracer [(11)C]K-2 to visualize and …
The glutamate alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) is an important molecule in neurotransmiss …
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Synthesis of [(18)F] fluorine-labeled K-2 derivatives as radiotracers for AMPA receptors.
Arisawa T, Kimura K, Miyazaki T, Takada Y, Nakajima W, Ota W, Ichijo S, Sano A, Hirao Y, Kurita JI, Nishimura Y, Takahashi T.
Arisawa T, et al.
Nucl Med Biol. 2022 Jul-Aug;110-111:47-58. doi: 10.1016/j.nucmedbio.2022.04.009. Epub 2022 Apr 30.
Nucl Med Biol. 2022.
PMID: 35642985
Free article.
A positron emission tomography (PET) tracer for AMPA receptors, [(11)C]K-2, was recently developed by us to visualize AMPA receptors in the living human brain. [(11)C]K-2 is a derivative of 4-[2-(phenyls …
A positron emission tomography (PET) tracer for AMPA receptors, [(11)C]K-2, was recently developed by us …
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Epileptic discharges initiate from brain areas with elevated accumulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors.
Miyazaki T, Takayama Y, Iwasaki M, Hatano M, Nakajima W, Ikegaya N, Yamamoto T, Tsuchimoto S, Kato H, Takahashi T.
Miyazaki T, et al.
Brain Commun. 2022 Feb 7;4(2):fcac023. doi: 10.1093/braincomms/fcac023. eCollection 2022.
Brain Commun. 2022.
PMID: 35415605
Free PMC article.
We have recently developed the first PET tracer for alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, [(11)C]K-2, to visualize and quantify the density of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors in living human …
We have recently developed the first PET tracer for alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor, [(11)C]K-2, to vi …
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