Visualization of regional tau deposits using (3)H-THK5117 in Alzheimer brain tissue.
Acta Neuropathol Commun. 2015.
PMID: 26134112
Free PMC article.
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Tau Oligomer-Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease.
JAMA Neurol. 2023 Nov 1;80(11):1209-1221. doi: 10.1001/jamaneurol.2023.3530.
JAMA Neurol. 2023.
PMID: 37812432
Free PMC article.
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional postmortem study included 40 human brains from the Massachusetts Alzheimer Disease Research Center Brain Bank with Braak III to IV stages of tau pathology but divergent antemortem cognition …
DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional postmortem study included 40 human brains from the Massachusetts Alzheimer …
Patterns of tau, amyloid and synuclein pathology in ageing, Alzheimer's disease and synucleinopathies.
Brain. 2025 May 13;148(5):1562-1576. doi: 10.1093/brain/awae372.
Brain. 2025.
PMID: 39531734
Free PMC article.
Alzheimer's disease (AD) is neuropathologically defined by deposits of misfolded hyperphosphorylated tau (HP-tau) and amyloid-beta. ...Our aims were to map regional quantitative pathology (HP-tau, amyloid-beta, alpha-synucle …
Alzheimer's disease (AD) is neuropathologically defined by deposits of misfolded hyperphosphorylated tau …
Cortical laminar tau deposits and activated astrocytes in Alzheimer's disease visualised by (3)H-THK5117 and (3)H-deprenyl autoradiography.
Sci Rep. 2017 Apr 4;7:45496. doi: 10.1038/srep45496.
Sci Rep. 2017.
PMID: 28374768
Free PMC article.
Hyperphosphorylated tau protein deposits and, inflammatory processes are characteristic components of Alzheimer disease (AD) pathology. ...Some variability was observed between the AD cases reflecting differences in disease phenotype. The simila …
Hyperphosphorylated tau protein deposits and, inflammatory processes are characteristic components of Alzheimer dise …
Amyloid Beta Immunoreactivity in the Retinal Ganglion Cell Layer of the Alzheimer's Eye.
Front Neurosci. 2020 Jul 31;14:758. doi: 10.3389/fnins.2020.00758. eCollection 2020.
Front Neurosci. 2020.
PMID: 32848548
Free PMC article.
Alzheimer's disease (AD) is the most prevalent form of dementia, accounting for 60-70% of all dementias. ...Although there is no known cure for AD, early diagnosis is important for disease management and care. A hallmark of AD is the deposition …
Alzheimer's disease (AD) is the most prevalent form of dementia, accounting for 60-70% of all dementias. ...Although th …
[(18)F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease.
Eur J Nucl Med Mol Imaging. 2015 Jun;42(7):1052-61. doi: 10.1007/s00259-015-3035-4. Epub 2015 Mar 20.
Eur J Nucl Med Mol Imaging. 2015.
PMID: 25792456
The purpose of the study was to evaluate the clinical utility of [(18)F]THK-5117 as a highly selective tau imaging radiotracer. METHODS: We initially evaluated in vitro binding of [(3)H]THK-5117 in post-mortem brain tissues from patients with Alzheimer …
The purpose of the study was to evaluate the clinical utility of [(18)F]THK-5117 as a highly selective tau imaging radiotracer. METHO …
[Alzheimer disease: cellular and molecular aspects].
Bull Mem Acad R Med Belg. 2005;160(10-12):445-9; discussion 450-1.
Bull Mem Acad R Med Belg. 2005.
PMID: 16768248
French.
A conclusive diagnosis of Alzheimer's disease (AD) can be made only by correlating clinical findings and neuropathological studies of post-mortem tissues. ...In the autopsy-derived AD brain, tau is hyperphosphorylated and more than 30 pho …
A conclusive diagnosis of Alzheimer's disease (AD) can be made only by correlating clinical findings and neuropathologi …
Neuronal Loss and alpha-Synuclein Pathology in the Superior Colliculus and Its Relationship to Visual Hallucinations in Dementia with Lewy Bodies.
Am J Geriatr Psychiatry. 2017 Jun;25(6):595-604. doi: 10.1016/j.jagp.2017.01.005. Epub 2017 Jan 10.
Am J Geriatr Psychiatry. 2017.
PMID: 28190674
METHODS: Postmortem superior colliculus tissue from 13 comparison, 10 DLB, and 10 Alzheimer disease (AD) cases was evaluated using quantitative neuropathologic methods. RESULTS: alpha-Synuclein and tau deposition were more severe in deeper layer …
METHODS: Postmortem superior colliculus tissue from 13 comparison, 10 DLB, and 10 Alzheimer disease (AD) cases was eval …
Visualization of regional tau deposits using (3)H-THK5117 in Alzheimer brain tissue.
Acta Neuropathol Commun. 2015 Jul 2;3:40. doi: 10.1186/s40478-015-0220-4.
Acta Neuropathol Commun. 2015.
PMID: 26134112
Free PMC article.
INTRODUCTION: The accumulation of neurofibrillary tangles, composed of aggregated hyperphosphorylated tau protein, starts spreading early in specific regions in the course of Alzheimer's disease (AD), correlating with the progression of memory …
INTRODUCTION: The accumulation of neurofibrillary tangles, composed of aggregated hyperphosphorylated tau protein, starts spreading …
Markers of Alzheimer's Disease in Primary Visual Cortex in Normal Aging in Mice.
Biomed Res Int. 2017;2017:3706018. doi: 10.1155/2017/3706018. Epub 2017 Sep 12.
Biomed Res Int. 2017.
PMID: 29138750
Free PMC article.
Aging is the principal risk factor for the development of Alzheimer's disease (AD). The hallmarks of AD are accumulation of the amyloid-beta peptide 1-42 (Abeta42) and abnormal hyperphosphorylation of Tau (p-Tau) protein in different areas of th …
Aging is the principal risk factor for the development of Alzheimer's disease (AD). The hallmarks of AD are accumulatio …
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