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107 results
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Application of metabolomics based on direct mass spectrometry analysis for the elucidation of altered metabolic pathways in serum from the APP/PS1 transgenic model of Alzheimer's disease.
González-Domínguez R, García-Barrera T, Vitorica J, Gómez-Ariza JL. González-Domínguez R, et al. Among authors: vitorica j. J Pharm Biomed Anal. 2015 Mar 25;107:378-85. doi: 10.1016/j.jpba.2015.01.025. Epub 2015 Jan 19. J Pharm Biomed Anal. 2015. PMID: 25656489 Free article.
Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative.
Navarro V, Sanchez-Mejias E, Jimenez S, Muñoz-Castro C, Sanchez-Varo R, Davila JC, Vizuete M, Gutierrez A, Vitorica J. Navarro V, et al. Among authors: vitorica j. Front Aging Neurosci. 2018 May 11;10:140. doi: 10.3389/fnagi.2018.00140. eCollection 2018. Front Aging Neurosci. 2018. PMID: 29867449 Free PMC article.
Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model.
Jimenez S, Torres M, Vizuete M, Sanchez-Varo R, Sanchez-Mejias E, Trujillo-Estrada L, Carmona-Cuenca I, Caballero C, Ruano D, Gutierrez A, Vitorica J. Jimenez S, et al. Among authors: vitorica j. J Biol Chem. 2011 May 27;286(21):18414-25. doi: 10.1074/jbc.M110.209718. Epub 2011 Apr 1. J Biol Chem. 2011. PMID: 21460223 Free PMC article.
Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic.
Jimenez S, Baglietto-Vargas D, Caballero C, Moreno-Gonzalez I, Torres M, Sanchez-Varo R, Ruano D, Vizuete M, Gutierrez A, Vitorica J. Jimenez S, et al. Among authors: vitorica j. J Neurosci. 2008 Nov 5;28(45):11650-61. doi: 10.1523/JNEUROSCI.3024-08.2008. J Neurosci. 2008. PMID: 18987201 Free PMC article.
Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus.
Torres M, Jimenez S, Sanchez-Varo R, Navarro V, Trujillo-Estrada L, Sanchez-Mejias E, Carmona I, Davila JC, Vizuete M, Gutierrez A, Vitorica J. Torres M, et al. Among authors: vitorica j. Mol Neurodegener. 2012 Nov 22;7:59. doi: 10.1186/1750-1326-7-59. Mol Neurodegener. 2012. PMID: 23173743 Free PMC article.
Extracellular amyloid-beta and cytotoxic glial activation induce significant entorhinal neuron loss in young PS1(M146L)/APP(751SL) mice.
Moreno-Gonzalez I, Baglietto-Vargas D, Sanchez-Varo R, Jimenez S, Trujillo-Estrada L, Sanchez-Mejias E, Del Rio JC, Torres M, Romero-Acebal M, Ruano D, Vizuete M, Vitorica J, Gutierrez A. Moreno-Gonzalez I, et al. Among authors: vitorica j. J Alzheimers Dis. 2009;18(4):755-76. doi: 10.3233/JAD-2009-1192. J Alzheimers Dis. 2009. PMID: 19661615
Inter-individual variability in the expression of the mutated form of hPS1M146L determined the production of Abeta peptides in the PS1xAPP transgenic mice.
Caballero C, Jimenez S, Moreno-Gonzalez I, Baglietto-Vargas D, Sanchez-Varo R, Gavilan MP, Ramos B, Del Rio JC, Vizuete M, Gutierrez A, Ruano D, Vitorica J. Caballero C, et al. Among authors: vitorica j. J Neurosci Res. 2007 Mar;85(4):787-97. doi: 10.1002/jnr.21172. J Neurosci Res. 2007. PMID: 17243176
107 results