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The phosphatidylinositol 3-Kinase AKT pathway in human cancer.
Vivanco I, Sawyers CL. Vivanco I, et al. Nat Rev Cancer. 2002 Jul;2(7):489-501. doi: 10.1038/nrc839. Nat Rev Cancer. 2002. PMID: 12094235 Review. No abstract available.
Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN.
Vivanco I, Palaskas N, Tran C, Finn SP, Getz G, Kennedy NJ, Jiao J, Rose J, Xie W, Loda M, Golub T, Mellinghoff IK, Davis RJ, Wu H, Sawyers CL. Vivanco I, et al. Cancer Cell. 2007 Jun;11(6):555-69. doi: 10.1016/j.ccr.2007.04.021. Cancer Cell. 2007. PMID: 17560336
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.
Mellinghoff IK, Wang MY, Vivanco I, Haas-Kogan DA, Zhu S, Dia EQ, Lu KV, Yoshimoto K, Huang JH, Chute DJ, Riggs BL, Horvath S, Liau LM, Cavenee WK, Rao PN, Beroukhim R, Peck TC, Lee JC, Sellers WR, Stokoe D, Prados M, Cloughesy TF, Sawyers CL, Mischel PS. Mellinghoff IK, et al. N Engl J Med. 2005 Nov 10;353(19):2012-24. doi: 10.1056/NEJMoa051918. N Engl J Med. 2005. PMID: 16282176
Inhibition of the phosphatidylinositol 3-kinase-Akt pathway enhances gamma-2 herpesvirus lytic replication and facilitates reactivation from latency.
Peng L, Wu TT, Tchieu JH, Feng J, Brown HJ, Feng J, Li X, Qi J, Deng H, Vivanco I, Mellinghoff IK, Jamieson C, Sun R. Peng L, et al. J Gen Virol. 2010 Feb;91(Pt 2):463-9. doi: 10.1099/vir.0.015073-0. Epub 2009 Oct 28. J Gen Virol. 2010. PMID: 19864499 Free PMC article.
Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death.
Graham NA, Tahmasian M, Kohli B, Komisopoulou E, Zhu M, Vivanco I, Teitell MA, Wu H, Ribas A, Lo RS, Mellinghoff IK, Mischel PS, Graeber TG. Graham NA, et al. Among authors: vivanco i. Mol Syst Biol. 2012 Jun 26;8:589. doi: 10.1038/msb.2012.20. Mol Syst Biol. 2012. PMID: 22735335 Free PMC article.
A kinase-independent function of AKT promotes cancer cell survival.
Vivanco I, Chen ZC, Tanos B, Oldrini B, Hsieh WY, Yannuzzi N, Campos C, Mellinghoff IK. Vivanco I, et al. Elife. 2014 Dec 31;3:e03751. doi: 10.7554/eLife.03751. Elife. 2014. PMID: 25551293 Free PMC article.
Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells.
Wang MY, Lu KV, Zhu S, Dia EQ, Vivanco I, Shackleford GM, Cavenee WK, Mellinghoff IK, Cloughesy TF, Sawyers CL, Mischel PS. Wang MY, et al. Cancer Res. 2006 Aug 15;66(16):7864-9. doi: 10.1158/0008-5472.CAN-04-4392. Cancer Res. 2006. PMID: 16912159
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