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Cost-effectiveness of screening type 2 diabetes patients for chronic kidney disease progression with the CKD273 urinary peptide classifier as compared to urinary albumin excretion.
Critselis E, Vlahou A, Stel VS, Morton RL. Critselis E, et al. Among authors: vlahou a. Nephrol Dial Transplant. 2018 Mar 1;33(3):441-449. doi: 10.1093/ndt/gfx068. Nephrol Dial Transplant. 2018. PMID: 29106632
A new urinary peptide classifier (CKD273) has exhibited greater ability to detect CKD progression, however, its cost-effectiveness remains unknown. ...METHODS: A decision-analytic Markov model was developed to estimate costs and health outcomes [including overall su
A new urinary peptide classifier (CKD273) has exhibited greater ability to detect CKD progression, however, its cost-effectiveness re
Proteomics approaches in the quest of kidney disease biomarkers.
Frantzi M, Bitsika V, Charonis A, Vlahou A. Frantzi M, et al. Among authors: vlahou a. Prilozi. 2011;32(2):33-51. Prilozi. 2011. PMID: 22286613 Review.
Proteomics refers to a group of analytical techniques for high throughput protein analysis, providing evidence for protein expression levels, subcellular localization, post-translational modifications and molecular interactions. ...A few examples from the applicatio …
Proteomics refers to a group of analytical techniques for high throughput protein analysis, providing evidence for protein expression …
Urinary proteomics and molecular determinants of chronic kidney disease: possible link to proteases.
Filip S, Pontillo C, Peter Schanstra J, Vlahou A, Mischak H, Klein J. Filip S, et al. Among authors: vlahou a. Expert Rev Proteomics. 2014 Oct;11(5):535-48. doi: 10.1586/14789450.2014.926224. Epub 2014 Jun 24. Expert Rev Proteomics. 2014. PMID: 24957818 Review.
Diagnosis and Prediction of CKD Progression by Assessment of Urinary Peptides.
Schanstra JP, Zürbig P, Alkhalaf A, Argiles A, Bakker SJ, Beige J, Bilo HJ, Chatzikyrkou C, Dakna M, Dawson J, Delles C, Haller H, Haubitz M, Husi H, Jankowski J, Jerums G, Kleefstra N, Kuznetsova T, Maahs DM, Menne J, Mullen W, Ortiz A, Persson F, Rossing P, Ruggenenti P, Rychlik I, Serra AL, Siwy J, Snell-Bergeon J, Spasovski G, Staessen JA, Vlahou A, Mischak H, Vanholder R. Schanstra JP, et al. Among authors: vlahou a. J Am Soc Nephrol. 2015 Aug;26(8):1999-2010. doi: 10.1681/ASN.2014050423. Epub 2015 Jan 14. J Am Soc Nephrol. 2015. PMID: 25589610 Free PMC article. Clinical Trial.
Progressive CKD is generally detected at a late stage by a sustained decline in eGFR and/or the presence of significant albuminuria. ...We validated that a previously established multipeptide urinary biomarker classifier performed significantly better in dete …
Progressive CKD is generally detected at a late stage by a sustained decline in eGFR and/or the presence of significant albumi …
Proteomic biomarkers in kidney disease: issues in development and implementation.
Mischak H, Delles C, Vlahou A, Vanholder R. Mischak H, et al. Among authors: vlahou a. Nat Rev Nephrol. 2015 Apr;11(4):221-32. doi: 10.1038/nrneph.2014.247. Epub 2015 Feb 3. Nat Rev Nephrol. 2015. PMID: 25643662 Review.
In addition, proteomic biomarkers could also be useful to define the most suitable therapeutic targets in a given patient or disease setting. ...
In addition, proteomic biomarkers could also be useful to define the most suitable therapeutic targets in a given patient or disease …
New insights in molecular mechanisms involved in chronic kidney disease using high-resolution plasma proteome analysis.
Glorieux G, Mullen W, Duranton F, Filip S, Gayrard N, Husi H, Schepers E, Neirynck N, Schanstra JP, Jankowski J, Mischak H, Argilés À, Vanholder R, Vlahou A, Klein J. Glorieux G, et al. Among authors: vlahou a. Nephrol Dial Transplant. 2015 Nov;30(11):1842-52. doi: 10.1093/ndt/gfv254. Epub 2015 Jul 9. Nephrol Dial Transplant. 2015. PMID: 26160894
Selected results were validated in a cohort of 40 patients with different CKD stages with or without HD, using ELISA. RESULTS: Of a total of 2054 detected proteins, 127 displayed lower, while 206 displayed higher abundance in the plasma of patients on HD. ...These r …
Selected results were validated in a cohort of 40 patients with different CKD stages with or without HD, using ELISA. RESULTS: Of …
Effect of Heme Oxygenase-1 Deficiency on Glomerular Proteomics.
Detsika MG, Lygirou V, Frantzis V, Zoidakis J, Atsaves V, Poulaki E, Gakiopoulou H, Vlahou A, Lianos EA. Detsika MG, et al. Among authors: vlahou a. Am J Nephrol. 2016;43(6):441-50. doi: 10.1159/000446859. Epub 2016 Jun 2. Am J Nephrol. 2016. PMID: 27251563
Western blot analysis of the integral slit diaphragm proteins, nephrin and podocin revealed a significant decrease in nephrin, with no change in podocin. ...CONCLUSION: HO-1 is a putative regulator of proteins important in preserving glomerular structural stability …
Western blot analysis of the integral slit diaphragm proteins, nephrin and podocin revealed a significant decrease in nephrin, with n …
A urinary proteome-based classifier for the early detection of decline in glomerular filtration.
Pontillo C, Jacobs L, Staessen JA, Schanstra JP, Rossing P, Heerspink HJL, Siwy J, Mullen W, Vlahou A, Mischak H, Vanholder R, Zürbig P, Jankowski J. Pontillo C, et al. Among authors: vlahou a. Nephrol Dial Transplant. 2017 Sep 1;32(9):1510-1516. doi: 10.1093/ndt/gfw239. Nephrol Dial Transplant. 2017. PMID: 27387473
BACKGROUND: Chronic kidney disease (CKD) progression is currently assessed by a decline in estimated glomerular filtration rate (eGFR) and/or an increase in urinary albumin excretion (UAE). ...METHODS: A total of 2672 patients with different CKD stages were included …
BACKGROUND: Chronic kidney disease (CKD) progression is currently assessed by a decline in estimated glomerular filtration rate (eGFR …
PeptiCKDdb-peptide- and protein-centric database for the investigation of genesis and progression of chronic kidney disease.
Krochmal M, Fernandes M, Filip S, Pontillo C, Husi H, Zoidakis J, Mischak H, Vlahou A, Jankowski J. Krochmal M, et al. Among authors: vlahou a. Database (Oxford). 2016 Sep 1;2016:baw128. doi: 10.1093/database/baw128. Print 2016. Database (Oxford). 2016. PMID: 27589965 Free PMC article.
A dedicated interactive web interface, equipped with multiparametric search engine, data export and visualization tools, enables easy browsing of the data and comprehensive analysis. In conclusion, this repository might serve as a source of data for integrative anal
A dedicated interactive web interface, equipped with multiparametric search engine, data export and visualization tools, enables easy
Noninvasive diagnosis of chronic kidney diseases using urinary proteome analysis.
Siwy J, Zürbig P, Argiles A, Beige J, Haubitz M, Jankowski J, Julian BA, Linde PG, Marx D, Mischak H, Mullen W, Novak J, Ortiz A, Persson F, Pontillo C, Rossing P, Rupprecht H, Schanstra JP, Vlahou A, Vanholder R. Siwy J, et al. Among authors: vlahou a. Nephrol Dial Transplant. 2017 Dec 1;32(12):2079-2089. doi: 10.1093/ndt/gfw337. Nephrol Dial Transplant. 2017. PMID: 27984204 Free PMC article.
A set of 706 samples served as the discovery cohort, and 474 samples were used for independent validation. For each CKD type, peptide biomarkers were defined using statistical analysis adjusted for multiple testing. ...
A set of 706 samples served as the discovery cohort, and 474 samples were used for independent validation. For each CKD type, peptide
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