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Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models.
Karpinar DP, Balija MB, Kügler S, Opazo F, Rezaei-Ghaleh N, Wender N, Kim HY, Taschenberger G, Falkenburger BH, Heise H, Kumar A, Riedel D, Fichtner L, Voigt A, Braus GH, Giller K, Becker S, Herzig A, Baldus M, Jäckle H, Eimer S, Schulz JB, Griesinger C, Zweckstetter M. Karpinar DP, et al. Among authors: voigt a. EMBO J. 2009 Oct 21;28(20):3256-68. doi: 10.1038/emboj.2009.257. Epub 2009 Sep 10. EMBO J. 2009. PMID: 19745811 Free PMC article.
The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity.
Butler EK, Voigt A, Lutz AK, Toegel JP, Gerhardt E, Karsten P, Falkenburger B, Reinartz A, Winklhofer KF, Schulz JB. Butler EK, et al. Among authors: voigt a. PLoS Genet. 2012 Feb;8(2):e1002488. doi: 10.1371/journal.pgen.1002488. Epub 2012 Feb 2. PLoS Genet. 2012. PMID: 22319455 Free PMC article.
TRAP1 rescues PINK1 loss-of-function phenotypes.
Zhang L, Karsten P, Hamm S, Pogson JH, Müller-Rischart AK, Exner N, Haass C, Whitworth AJ, Winklhofer KF, Schulz JB, Voigt A. Zhang L, et al. Among authors: voigt a. Hum Mol Genet. 2013 Jul 15;22(14):2829-41. doi: 10.1093/hmg/ddt132. Epub 2013 Mar 21. Hum Mol Genet. 2013. PMID: 23525905 Free PMC article.
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