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Mechanical unloading of the heart activates the calpain system.
Razeghi P, Volpini KC, Wang ME, Youker KA, Stepkowski S, Taegtmeyer H. Razeghi P, et al. Among authors: volpini kc. J Mol Cell Cardiol. 2007 Feb;42(2):449-52. doi: 10.1016/j.yjmcc.2006.08.114. Epub 2006 Oct 4. J Mol Cell Cardiol. 2007. PMID: 17027024