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Salvinorin A: from natural product to human therapeutics.
Vortherms TA, Roth BL. Vortherms TA, et al. Mol Interv. 2006 Oct;6(5):257-65. doi: 10.1124/mi.6.5.7. Mol Interv. 2006. PMID: 17035666 Review.
Differential helical orientations among related G protein-coupled receptors provide a novel mechanism for selectivity. Studies with salvinorin A and the kappa-opioid receptor.
Vortherms TA, Mosier PD, Westkaemper RB, Roth BL. Vortherms TA, et al. J Biol Chem. 2007 Feb 2;282(5):3146-56. doi: 10.1074/jbc.M609264200. Epub 2006 Nov 22. J Biol Chem. 2007. PMID: 17121830
Autoxidation of salvinorin A under basic conditions.
Munro TA, Goetchius GW, Roth BL, Vortherms TA, Rizzacasa MA. Munro TA, et al. J Org Chem. 2005 Nov 25;70(24):10057-61. doi: 10.1021/jo051813e. J Org Chem. 2005. PMID: 16292839 Free PMC article.
Receptorome screening for CNS drug discovery.
Vortherms TA, Roth BL. Vortherms TA, et al. IDrugs. 2005 Jun;8(6):491-6. IDrugs. 2005. PMID: 15906196 Review.
Using molecular tools to dissect the role of Galphas in sensitization of AC1.
Vortherms TA, Nguyen CH, Berlot CH, Watts VJ. Vortherms TA, et al. Mol Pharmacol. 2004 Dec;66(6):1617-24. doi: 10.1124/mol.104.000166. Epub 2004 Sep 10. Mol Pharmacol. 2004. PMID: 15361543
D2 dopamine receptor-induced sensitization of adenylyl cyclase type 1 is G alpha(s) independent.
Vortherms TA, Nguyen CH, Bastepe M, J├╝ppner H, Watts VJ. Vortherms TA, et al. Neuropharmacology. 2006 Apr;50(5):576-84. doi: 10.1016/j.neuropharm.2005.11.004. Epub 2005 Dec 27. Neuropharmacology. 2006. PMID: 16376953
Synthesis and SAR of 4-aminocyclopentapyrrolidines as orally active N-type calcium channel inhibitors for inflammatory and neuropathic pain.
Beebe X, Yeung CM, Darczak D, Shekhar S, Vortherms TA, Miller L, Milicic I, Swensen AM, Zhu CZ, Banfor P, Wetter JM, Marsh KC, Jarvis MF, Scott VE, Schrimpf MR, Lee CH. Beebe X, et al. Among authors: vortherms ta. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4857-61. doi: 10.1016/j.bmcl.2013.06.074. Epub 2013 Jul 4. Bioorg Med Chem Lett. 2013. PMID: 23876987
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