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Lovastatin induces mitotic abnormalities in various cell lines.
Lamprecht J, Wójcik C, Jakóbisiak M, Stoehr M, Schrorter D, Paweletz N. Lamprecht J, et al. Cell Biol Int. 1999;23(1):51-60. doi: 10.1006/cbir.1998.0322. Cell Biol Int. 1999. PMID: 10527548
Separation of cathepsin A-like enzyme and the proteasome: evidence that lactacystin/beta-lactone is not a specific inhibitor of the proteasome.
Ostrowska H, Wójcik C, Wilk S, Omura S, Kozlowski L, Stoklosa T, Worowski K, Radziwon P. Ostrowska H, et al. Int J Biochem Cell Biol. 2000 Jul;32(7):747-57. doi: 10.1016/s1357-2725(00)00021-2. Int J Biochem Cell Biol. 2000. PMID: 10856705
In the present study we discard the first possibility on the basis of the following findings: (a) human platelet cathepsin A, unlike proteasome, binds to concanavalin A, and does not bind to Heparin-Sepharose at pH 7.4; (b) neither the chymotrypsin-like activity of the proteasome …
In the present study we discard the first possibility on the basis of the following findings: (a) human platelet cathepsin A, unlike proteas …
Effects of an inhibitor of tripeptidyl peptidase II (Ala-Ala-Phe-chloromethylketone) and its combination with an inhibitor of the chymotrypsin-like activity of the proteasome (PSI) on apoptosis, cell cycle and proteasome activity in U937 cells.
Bury M, Młynarczuk I, Pleban E, Hoser G, Kawiak J, Wójcik C. Bury M, et al. Folia Histochem Cytobiol. 2001;39(2):131-2. Folia Histochem Cytobiol. 2001. PMID: 11374791
Lovastatin and simvastatin are modulators of the proteasome.
Wójcik C, Bury M, Stoklosa T, Giermasz A, Feleszko W, Mlynarczuk I, Pleban E, Basak G, Omura S, Jakóbisiak M. Wójcik C, et al. Int J Biochem Cell Biol. 2000 Sep;32(9):957-65. doi: 10.1016/s1357-2725(00)00044-3. Int J Biochem Cell Biol. 2000. PMID: 11084375
The closed ring form of lovastatin is much more potent as a cytotoxic agent on the Colon-26 (C-26) colon carcinoma cell line than the opened ring form, which is only mildly cytostatic. ...In contrast with the opened ring form of lovastatin, the closed ring form induces the …
The closed ring form of lovastatin is much more potent as a cytotoxic agent on the Colon-26 (C-26) colon carcinoma cell line than the …
Are proteasomes involved in the formation of the kinetochore?
Paweletz N, Wójcik C, Schroeter D, Finze EM. Paweletz N, et al. Chromosome Res. 1996 Sep;4(6):436-42. doi: 10.1007/BF02265050. Chromosome Res. 1996. PMID: 8889242
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