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37 results

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Page 1
Long-term hormone therapy for perimenopausal and postmenopausal women.
Marjoribanks J, Farquhar C, Roberts H, Lethaby A, Lee J. Marjoribanks J, et al. Cochrane Database Syst Rev. 2017 Jan 17;1(1):CD004143. doi: 10.1002/14651858.CD004143.pub5. Cochrane Database Syst Rev. 2017. Update in: Cochrane Database Syst Rev. 2025 Nov 27;11:CD004143. doi: 10.1002/14651858.CD004143.pub6. PMID: 28093732 Free PMC article. Updated.
BACKGROUND: Hormone therapy (HT) is widely provided for control of menopausal symptoms and has been used for the management and prevention of cardiovascular disease, osteoporosis and dementia in older women. ...Although HT is considered effective for the prevention …
BACKGROUND: Hormone therapy (HT) is widely provided for control of menopausal symptoms and has been used for the management an …
Estrogens and breast cancer.
Kim J, Munster PN. Kim J, et al. Ann Oncol. 2025 Feb;36(2):134-148. doi: 10.1016/j.annonc.2024.10.824. Epub 2024 Nov 8. Ann Oncol. 2025. PMID: 39522613 Free PMC article. Review.
Estrogen-plus-progestin hormone replacement therapy (HRT) has consistently shown an increase in breast cancer risk among postmenopausal women, whereas estrogen-alone HRT has little impact on breast cancer risk in naturally or surgically menopausal women. In particul …
Estrogen-plus-progestin hormone replacement therapy (HRT) has consistently shown an increase in breast cancer risk among postm …
The Women's Health Initiative Randomized Trials and Clinical Practice: A Review.
Manson JE, Crandall CJ, Rossouw JE, Chlebowski RT, Anderson GL, Stefanick ML, Aragaki AK, Cauley JA, Wells GL, LaCroix AZ, Thomson CA, Neuhouser ML, Van Horn L, Kooperberg C, Howard BV, Tinker LF, Wactawski-Wende J, Shumaker SA, Prentice RL. Manson JE, et al. JAMA. 2024 May 28;331(20):1748-1760. doi: 10.1001/jama.2024.6542. JAMA. 2024. PMID: 38691368 Review.
These benefits of hormone therapy in early menopause, combined with lower rates of adverse effects of hormone therapy in early compared with later menopause, support initiation of hormone therapy before age 60 years for women without cont …
These benefits of hormone therapy in early menopause, combined with lower rates of adverse effects of hormone therap …
Long-term hormone therapy for perimenopausal and postmenopausal women.
Bofill Rodriguez M, Yong LN, Mirkov S, Bekos C, Lethaby A, Farquhar C. Bofill Rodriguez M, et al. Cochrane Database Syst Rev. 2025 Nov 27;11(11):CD004143. doi: 10.1002/14651858.CD004143.pub6. Cochrane Database Syst Rev. 2025. PMID: 41307293
We focused on studies assessing hormone therapy's effects on long-term clinical outcomes, including death, coronary events and cancer. ...The main limitation was that only about 30% of women were 50 to 59 years old at baseline, the age group mos …
We focused on studies assessing hormone therapy's effects on long-term clinical outcomes, including death …
Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality: The Women's Health Initiative Randomized Trials.
Manson JE, Aragaki AK, Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Chlebowski RT, Howard BV, Thomson CA, Margolis KL, Lewis CE, Stefanick ML, Jackson RD, Johnson KC, Martin LW, Shumaker SA, Espeland MA, Wactawski-Wende J; WHI Investigators. Manson JE, et al. JAMA. 2017 Sep 12;318(10):927-938. doi: 10.1001/jama.2017.11217. JAMA. 2017. PMID: 28898378 Free PMC article. Clinical Trial.
OBJECTIVE: To examine total and cause-specific cumulative mortality, including during the intervention and extended postintervention follow-up, of the 2 Women's Health Initiative hormone therapy trials. DESIGN, SETTING, AND PARTICIPANTS: Observational foll …
OBJECTIVE: To examine total and cause-specific cumulative mortality, including during the intervention and extended postintervention foll …
Breast cancer incidence and mortality by metabolic syndrome and obesity: The Women's Health Initiative.
Chlebowski RT, Aragaki AK, Pan K, Simon MS, Neuhouser ML, Haque R, Rohan TE, Wactawski-Wende J, Orchard TS, Mortimer JE, Lane D, Kaunitz AM, Desai P, Wild RA, Barac A, Manson JE. Chlebowski RT, et al. Cancer. 2024 Sep 15;130(18):3147-3156. doi: 10.1002/cncr.35318. Epub 2024 May 13. Cancer. 2024. PMID: 38736319 Free article. Clinical Trial.
Therefore, this study investigated the associations of MetS and obesity with postmenopausal breast cancer after long-term follow-up in the WHI clinical trials. METHODS: A total of 68,132 postmenopausal women, without prior breast cancer and with normal …
Therefore, this study investigated the associations of MetS and obesity with postmenopausal breast cancer after long-term f …
Long term hormone therapy for perimenopausal and postmenopausal women.
Marjoribanks J, Farquhar C, Roberts H, Lethaby A. Marjoribanks J, et al. Cochrane Database Syst Rev. 2012 Jul 11;(7):CD004143. doi: 10.1002/14651858.CD004143.pub4. Cochrane Database Syst Rev. 2012. Update in: Cochrane Database Syst Rev. 2017 Jan 17;1:CD004143. doi: 10.1002/14651858.CD004143.pub5. PMID: 22786488 Updated.
BACKGROUND: Hormone therapy (HT) is widely used for controlling menopausal symptoms and has also been used for the management and prevention of cardiovascular disease, osteoporosis and dementia in older women. ...Among women with cardiovascular disease, long …
BACKGROUND: Hormone therapy (HT) is widely used for controlling menopausal symptoms and has also been used for the management …
No increased death toll for long-term menopausal hormone therapy.
Pines A. Pines A. Climacteric. 2017 Dec;20(6):531-532. doi: 10.1080/13697137.2017.1386651. Epub 2017 Oct 23. Climacteric. 2017. PMID: 29057667
Now, 15 years after the first release of the WHI data, long-term follow-up of the WHI cohort enables consideration of mortality records as well. These data were recently summarized by the WHI investigators as follows: 'Among postme …
Now, 15 years after the first release of the WHI data, long-term follow-up of the WHI cohort enables cons …
WHI and WHIMS follow-up and human studies of soy isoflavones on cognition.
Zhao L, Brinton RD. Zhao L, et al. Expert Rev Neurother. 2007 Nov;7(11):1549-64. doi: 10.1586/14737175.7.11.1549. Expert Rev Neurother. 2007. PMID: 17997703 Review.
Recent follow-up analyses of the previous findings from the Women's Health Initiative and the Women's Health Initiative Memory Study confirmed some health benefits of estrogen-containing hormone therapy (HT) in women within 10 years from the onset of menopaus …
Recent follow-up analyses of the previous findings from the Women's Health Initiative and the Women's Health Initiative Memory Study …
Estrogen Plus Progestin and Colorectal Cancer: Long-Term Findings From the Women's Health Initiative Randomized Clinical Trial.
Chlebowski RT, Aragaki AK, Pan K, Luo J, Rohan TE, Johnson KC, Wactawski-Wende J, Jung SY, Xiao Q, Lavasani S, Manson JE, Simon MS. Chlebowski RT, et al. J Clin Oncol. 2024 Oct 20;42(30):3530-3536. doi: 10.1200/JCO.23.02092. Epub 2024 Jul 19. J Clin Oncol. 2024. PMID: 39028918 Free PMC article. Clinical Trial.
Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.We report long-term colorectal cancer findings from the Women's Health Initiative t …
Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the p …
37 results