Wacher VJ - Search Results

1

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

Wacher VJ, Wu CY, Benet LZ. Wacher VJ, et al. Mol Carcinog. 1995 Jul;13(3):129-34. doi: 10.1002/mc.2940130302. Mol Carcinog. 1995. PMID: 7619215 Review. No abstract available.

2

Sirolimus oral absorption in rats is increased by ketoconazole but is not affected by D-alpha-tocopheryl poly(ethylene glycol 1000) succinate.

Wacher VJ, Silverman JA, Wong S, Tran-Tau P, Chan AO, Chai A, Yu XQ, O'Mahony D, Ramtoola Z. Wacher VJ, et al. J Pharmacol Exp Ther. 2002 Oct;303(1):308-13. doi: 10.1124/jpet.102.036541. J Pharmacol Exp Ther. 2002. PMID: 12235265

3

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery.

Benet LZ, Izumi T, Zhang Y, Silverman JA, Wacher VJ. Benet LZ, et al. Among authors: wacher vj. J Control Release. 1999 Nov 1;62(1-2):25-31. doi: 10.1016/s0168-3659(99)00034-6. J Control Release. 1999. PMID: 10518631

4

Grapefruit juice activates P-glycoprotein-mediated drug transport.

Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. Soldner A, et al. Among authors: wacher vj. Pharm Res. 1999 Apr;16(4):478-85. doi: 10.1023/a:1011902625609. Pharm Res. 1999. PMID: 10227700

5

Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics.

Wacher VJ, Silverman JA, Zhang Y, Benet LZ. Wacher VJ, et al. J Pharm Sci. 1998 Nov;87(11):1322-30. doi: 10.1021/js980082d. J Pharm Sci. 1998. PMID: 9811484 Review.

6

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine.

Gomez DY, Wacher VJ, Tomlanovich SJ, Hebert MF, Benet LZ. Gomez DY, et al. Among authors: wacher vj. Clin Pharmacol Ther. 1995 Jul;58(1):15-9. doi: 10.1016/0009-9236(95)90067-5. Clin Pharmacol Ther. 1995. PMID: 7628178 Clinical Trial.

7

Time course of cyclosporine and ist motabolites in blood, liver and spleen of naive Lewis rats: comparison with preliminary data obtained in transplanted animals.

Wacher VJ, Liu T, Roberts JP, Ascher NL, Benet LZ. Wacher VJ, et al. Biopharm Drug Dispos. 1995 May;16(4):303-12. doi: 10.1002/bdd.2510160406. Biopharm Drug Dispos. 1995. PMID: 7548779

8

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine.

Wu CY, Benet LZ, Hebert MF, Gupta SK, Rowland M, Gomez DY, Wacher VJ. Wu CY, et al. Among authors: wacher vj. Clin Pharmacol Ther. 1995 Nov;58(5):492-7. doi: 10.1016/0009-9236(95)90168-X. Clin Pharmacol Ther. 1995. PMID: 7586942

9

Minimal effect of ketoconazole on cyclosporine (SangCyA) oral absorption and first-pass metabolism in rats: evidence of a significant vehicle effect on SangCyA absorption.

Wong S, Wong HT, Wacher VJ. Wong S, et al. Among authors: wacher vj. Biopharm Drug Dispos. 2002 Mar;23(2):53-7. doi: 10.1002/bdd.295. Biopharm Drug Dispos. 2002. PMID: 11932959

10

Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo.

Dresser GK, Wacher V, Wong S, Wong HT, Bailey DG. Dresser GK, et al. Clin Pharmacol Ther. 2002 Sep;72(3):247-55. doi: 10.1067/mcp.2002.126409. Clin Pharmacol Ther. 2002. PMID: 12235445 Clinical Trial.

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