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The Trp53 delta proline (Trp53ΔP) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development.
Adams CJ, Yu JS, Mao JH, Jen KY, Costes SV, Wade M, Shoemake J, Aina OH, Del Rosario R, Menchavez PT, Cardiff RD, Wahl GM, Balmain A. Adams CJ, et al. Among authors: wade m. Mol Carcinog. 2016 Sep;55(9):1387-96. doi: 10.1002/mc.22377. Epub 2015 Aug 27. Mol Carcinog. 2016. PMID: 26310697 Free PMC article.
The p53 orchestra: Mdm2 and Mdmx set the tone.
Wade M, Wang YV, Wahl GM. Wade M, et al. Trends Cell Biol. 2010 May;20(5):299-309. doi: 10.1016/j.tcb.2010.01.009. Epub 2010 Feb 19. Trends Cell Biol. 2010. PMID: 20172729 Free PMC article. Review.
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