Wafford KA - Search Results

1

A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.

Lewis RT, Blackaby WP, Blackburn T, Jennings AS, Pike A, Wilson RA, Hallett DJ, Cook SM, Ferris P, Marshall GR, Reynolds DS, Sheppard WF, Smith AJ, Sohal B, Stanley J, Tye SJ, Wafford KA, Atack JR. Lewis RT, et al. Among authors: wafford ka. J Med Chem. 2006 Apr 20;49(8):2600-10. doi: 10.1021/jm051144x. J Med Chem. 2006. PMID: 16610803

2

6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists.

Chambers MS, Atack JR, Bromidge FA, Broughton HB, Cook S, Dawson GR, Hobbs SC, Maubach KA, Reeve AJ, Seabrook GR, Wafford K, MacLeod AM. Chambers MS, et al. Among authors: wafford k. J Med Chem. 2002 Mar 14;45(6):1176-9. doi: 10.1021/jm010471b. J Med Chem. 2002. PMID: 11881985

3

3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels.

Collins I, Moyes C, Davey WB, Rowley M, Bromidge FA, Quirk K, Atack JR, McKernan RM, Thompson SA, Wafford K, Dawson GR, Pike A, Sohal B, Tsou NN, Ball RG, Castro JL. Collins I, et al. J Med Chem. 2002 Apr 25;45(9):1887-900. doi: 10.1021/jm0110789. J Med Chem. 2002. PMID: 11960500

4

Tricyclic pyridones as functionally selective human GABAA alpha 2/3 receptor-ion channel ligands.

Crawforth J, Atack JR, Cook SM, Gibson KR, Nadin A, Owens AP, Pike A, Rowley M, Smith AJ, Sohal B, Sternfeld F, Wafford K, Street LJ. Crawforth J, et al. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1679-82. doi: 10.1016/j.bmcl.2004.01.057. Bioorg Med Chem Lett. 2004. PMID: 15026049

5

Selective, orally active gamma-aminobutyric acidA alpha5 receptor inverse agonists as cognition enhancers.

Sternfeld F, Carling RW, Jelley RA, Ladduwahetty T, Merchant KJ, Moore KW, Reeve AJ, Street LJ, O'Connor D, Sohal B, Atack JR, Cook S, Seabrook G, Wafford K, Tattersall FD, Collinson N, Dawson GR, Castro JL, MacLeod AM. Sternfeld F, et al. J Med Chem. 2004 Apr 22;47(9):2176-9. doi: 10.1021/jm031076j. J Med Chem. 2004. PMID: 15084116

6

2,5-Dihydropyrazolo[4,3-c]pyridin-3-ones: functionally selective benzodiazepine binding site ligands on the GABAA receptor.

Mitchinson A, Atack JR, Blurton P, Carling RW, Castro JL, Curley KS, Russell MG, Marshall G, McKernan RM, Moore KW, Narquizian R, Smith A, Street LJ, Thompson SA, Wafford K. Mitchinson A, et al. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3441-4. doi: 10.1016/j.bmcl.2004.04.085. Bioorg Med Chem Lett. 2004. PMID: 15177449

7

Anxiogenic properties of an inverse agonist selective for alpha3 subunit-containing GABA A receptors.

Atack JR, Hutson PH, Collinson N, Marshall G, Bentley G, Moyes C, Cook SM, Collins I, Wafford K, McKernan RM, Dawson GR. Atack JR, et al. Br J Pharmacol. 2005 Feb;144(3):357-66. doi: 10.1038/sj.bjp.0706056. Br J Pharmacol. 2005. PMID: 15655523 Free PMC article.

8

Pyrazolopyridinones as functionally selective GABAA ligands.

Blackaby WP, Atack JR, Bromidge F, Lewis R, Russell MG, Smith A, Wafford K, McKernan RM, Street LJ, Castro JL. Blackaby WP, et al. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4998-5002. doi: 10.1016/j.bmcl.2005.08.006. Bioorg Med Chem Lett. 2005. PMID: 16153832

9

3-phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and analogues: high-affinity gamma-aminobutyric acid-A benzodiazepine receptor ligands with alpha 2, alpha 3, and alpha 5-subtype binding selectivity over alpha 1.

Carling RW, Moore KW, Street LJ, Wild D, Isted C, Leeson PD, Thomas S, O'Connor D, McKernan RM, Quirk K, Cook SM, Atack JR, Wafford KA, Thompson SA, Dawson GR, Ferris P, Castro JL. Carling RW, et al. Among authors: wafford ka. J Med Chem. 2004 Mar 25;47(7):1807-22. doi: 10.1021/jm031020p. J Med Chem. 2004. PMID: 15027873

10

Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site.

Street LJ, Sternfeld F, Jelley RA, Reeve AJ, Carling RW, Moore KW, McKernan RM, Sohal B, Cook S, Pike A, Dawson GR, Bromidge FA, Wafford KA, Seabrook GR, Thompson SA, Marshall G, Pillai GV, Castro JL, Atack JR, MacLeod AM. Street LJ, et al. Among authors: wafford ka. J Med Chem. 2004 Jul 1;47(14):3642-57. doi: 10.1021/jm0407613. J Med Chem. 2004. PMID: 15214791

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

151 results

Search Page