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The Wnt-1 (int-1) oncogene promoter and its mechanism of activation by insertion of proviral DNA of the mouse mammary tumor virus.
Nusse R, Theunissen H, Wagenaar E, Rijsewijk F, Gennissen A, Otte A, Schuuring E, van Ooyen A. Nusse R, et al. Mol Cell Biol. 1990 Aug;10(8):4170-9. doi: 10.1128/mcb.10.8.4170. Mol Cell Biol. 1990. PMID: 1695322 Free PMC article.
Wnt-3, a gene activated by proviral insertion in mouse mammary tumors, is homologous to int-1/Wnt-1 and is normally expressed in mouse embryos and adult brain.
Roelink H, Wagenaar E, Lopes da Silva S, Nusse R. Roelink H, et al. Proc Natl Acad Sci U S A. 1990 Jun;87(12):4519-23. doi: 10.1073/pnas.87.12.4519. Proc Natl Acad Sci U S A. 1990. PMID: 2162045 Free PMC article.
Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease.
Smit JJ, Schinkel AH, Oude Elferink RP, Groen AK, Wagenaar E, van Deemter L, Mol CA, Ottenhoff R, van der Lugt NM, van Roon MA, et al. Smit JJ, et al. Cell. 1993 Nov 5;75(3):451-62. doi: 10.1016/0092-8674(93)90380-9. Cell. 1993. PMID: 8106172
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.
Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Robanus-Maandag EC, te Riele HP, et al. Schinkel AH, et al. Cell. 1994 May 20;77(4):491-502. doi: 10.1016/0092-8674(94)90212-7. Cell. 1994. PMID: 7910522
Bcrp1;Mdr1a/b;Mrp2 combination knockout mice: altered disposition of the dietary carcinogen PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) and its genotoxic metabolites.
Vlaming ML, Teunissen SF, van de Steeg E, van Esch A, Wagenaar E, Brunsveld L, de Greef TF, Rosing H, Schellens JH, Beijnen JH, Schinkel AH. Vlaming ML, et al. Mol Pharmacol. 2014 Mar;85(3):520-30. doi: 10.1124/mol.113.088823. Epub 2013 Dec 13. Mol Pharmacol. 2014. PMID: 24334255
Murine Oatp1a/1b uptake transporters control rosuvastatin systemic exposure without affecting its apparent liver exposure.
Iusuf D, van Esch A, Hobbs M, Taylor M, Kenworthy KE, van de Steeg E, Wagenaar E, Schinkel AH. Iusuf D, et al. Mol Pharmacol. 2013 May;83(5):919-29. doi: 10.1124/mol.112.081927. Epub 2013 Feb 19. Mol Pharmacol. 2013. PMID: 23429889
Hepatic clearance of reactive glucuronide metabolites of diclofenac in the mouse is dependent on multiple ATP-binding cassette efflux transporters.
Lagas JS, Sparidans RW, Wagenaar E, Beijnen JH, Schinkel AH. Lagas JS, et al. Mol Pharmacol. 2010 Apr;77(4):687-94. doi: 10.1124/mol.109.062364. Epub 2010 Jan 19. Mol Pharmacol. 2010. PMID: 20086033
Multidrug transporter ABCG2/breast cancer resistance protein secretes riboflavin (vitamin B2) into milk.
van Herwaarden AE, Wagenaar E, Merino G, Jonker JW, Rosing H, Beijnen JH, Schinkel AH. van Herwaarden AE, et al. Mol Cell Biol. 2007 Feb;27(4):1247-53. doi: 10.1128/MCB.01621-06. Epub 2006 Dec 4. Mol Cell Biol. 2007. PMID: 17145775 Free PMC article.
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