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3,771 results
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Hypoxia-inducible factor-1α (HIF-1α) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions.
Yi T, Papadopoulos E, Hagner PR, Wagner G. Yi T, et al. Among authors: wagner g. J Biol Chem. 2013 Jun 28;288(26):18732-42. doi: 10.1074/jbc.M113.471466. Epub 2013 May 10. J Biol Chem. 2013. PMID: 23667251 Free PMC article.
Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation.
Kozel C, Thompson B, Hustak S, Moore C, Nakashima A, Singh CR, Reid M, Cox C, Papadopoulos E, Luna RE, Anderson A, Tagami H, Hiraishi H, Slone EA, Yoshino KI, Asano M, Gillaspie S, Nietfeld J, Perchellet JP, Rothenburg S, Masai H, Wagner G, Beeser A, Kikkawa U, Fleming SD, Asano K. Kozel C, et al. Among authors: wagner g. Nucleic Acids Res. 2016 Oct 14;44(18):8704-8713. doi: 10.1093/nar/gkw559. Epub 2016 Jun 20. Nucleic Acids Res. 2016. PMID: 27325740 Free PMC article.
Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression.
Hiraishi H, Oatman J, Haller SL, Blunk L, McGivern B, Morris J, Papadopoulos E, Gutierrez W, Gordon M, Bokhari W, Ikeda Y, Miles D, Fellers J, Asano M, Wagner G, Tazi L, Rothenburg S, Brown SJ, Asano K. Hiraishi H, et al. Among authors: wagner g. Nucleic Acids Res. 2014;42(16):10321-30. doi: 10.1093/nar/gku670. Epub 2014 Aug 21. Nucleic Acids Res. 2014. PMID: 25147208 Free PMC article.
Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.
Obayashi E, Luna RE, Nagata T, Martin-Marcos P, Hiraishi H, Singh CR, Erzberger JP, Zhang F, Arthanari H, Morris J, Pellarin R, Moore C, Harmon I, Papadopoulos E, Yoshida H, Nasr ML, Unzai S, Thompson B, Aube E, Hustak S, Stengel F, Dagraca E, Ananbandam A, Gao P, Urano T, Hinnebusch AG, Wagner G, Asano K. Obayashi E, et al. Among authors: wagner g. Cell Rep. 2017 Mar 14;18(11):2651-2663. doi: 10.1016/j.celrep.2017.02.052. Cell Rep. 2017. PMID: 28297669 Free PMC article.
Structural basis for the enhancement of eIF4A helicase activity by eIF4G.
Oberer M, Marintchev A, Wagner G. Oberer M, et al. Among authors: wagner g. Genes Dev. 2005 Sep 15;19(18):2212-23. doi: 10.1101/gad.1335305. Genes Dev. 2005. PMID: 16166382 Free PMC article.
Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major.
Meleppattu S, Arthanari H, Zinoviev A, Boeszoermenyi A, Wagner G, Shapira M, Léger-Abraham M. Meleppattu S, et al. Among authors: wagner g. Nucleic Acids Res. 2018 Apr 20;46(7):3791-3801. doi: 10.1093/nar/gky194. Nucleic Acids Res. 2018. PMID: 29562352 Free PMC article.
Cytocapsular tubes conduct cell translocation.
Yi T, Wagner G. Yi T, et al. Among authors: wagner g. Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1137-E1146. doi: 10.1073/pnas.1717910115. Epub 2018 Jan 16. Proc Natl Acad Sci U S A. 2018. PMID: 29339492 Free PMC article.
An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation.
Imai S, Kumar P, Hellen CU, D'Souza VM, Wagner G. Imai S, et al. Among authors: wagner g. Nat Struct Mol Biol. 2016 Sep;23(9):859-64. doi: 10.1038/nsmb.3280. Epub 2016 Aug 15. Nat Struct Mol Biol. 2016. PMID: 27525590 Free PMC article.
Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1.
Sekiyama N, Arthanari H, Papadopoulos E, Rodriguez-Mias RA, Wagner G, Léger-Abraham M. Sekiyama N, et al. Among authors: wagner g. Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4036-45. doi: 10.1073/pnas.1512118112. Epub 2015 Jul 13. Proc Natl Acad Sci U S A. 2015. PMID: 26170285 Free PMC article.
Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.
Papadopoulos E, Jenni S, Kabha E, Takrouri KJ, Yi T, Salvi N, Luna RE, Gavathiotis E, Mahalingam P, Arthanari H, Rodriguez-Mias R, Yefidoff-Freedman R, Aktas BH, Chorev M, Halperin JA, Wagner G. Papadopoulos E, et al. Among authors: wagner g. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3187-95. doi: 10.1073/pnas.1410250111. Epub 2014 Jul 21. Proc Natl Acad Sci U S A. 2014. PMID: 25049413 Free PMC article.
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