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Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells.
Vabulas RM, Ahmad-Nejad P, da Costa C, Miethke T, Kirschning CJ, Häcker H, Wagner H. Vabulas RM, et al. J Biol Chem. 2001 Aug 17;276(33):31332-9. doi: 10.1074/jbc.M103217200. Epub 2001 Jun 11. J Biol Chem. 2001. PMID: 11402040
Synthetic endotoxin-binding peptides block endotoxin-triggered TNF-alpha production by macrophages in vitro and in vivo and prevent endotoxin-mediated toxic shock.
Dankesreiter S, Hoess A, Schneider-Mergener J, Wagner H, Miethke T. Dankesreiter S, et al. J Immunol. 2000 May 1;164(9):4804-11. doi: 10.4049/jimmunol.164.9.4804. J Immunol. 2000. PMID: 10779788
As compared with other peptides, only LL-10-H-14 is able to strongly decrease endotoxin-stimulated TNF-alpha release by human macrophage cell lines as well as by PBMC. ...As such, LL-10-H-14 could have prophylactic and/or therapeutic properties in humans for the man …
As compared with other peptides, only LL-10-H-14 is able to strongly decrease endotoxin-stimulated TNF-alpha release by human macroph …
Reactivity of Ly-2+ T cells against 2,4,6-trinitrophenyl (TNP)-modified syngeneic stimulator cells: specificity, frequency of interleukin 2-producing Ly-2+ helper T cells and clonal segregation from Ly-2+ cytotoxic T lymphocytes.
Schmitt J, Wagner H, Heeg K. Schmitt J, et al. Eur J Immunol. 1988 Mar;18(3):325-32. doi: 10.1002/eji.1830180302. Eur J Immunol. 1988. PMID: 2965642
TNP-specific Ly-2+ IL-2 TL used class I MHC (H-2Kk) gene products as major histocompatibility complex (MHC) restriction elements, while L3T4+ IL 2 TL proved to be class II MHC (H-2I-AkI-Ek) restricted. ...
TNP-specific Ly-2+ IL-2 TL used class I MHC (H-2Kk) gene products as major histocompatibility complex (MHC) restriction elements, whi …
Cyclosporine A prevents the generation of single positive (Lyt2+ L3T4-, Lyt2- L3T4+) mature T cells, but not single positive (Lyt2+ T3-) Immature thymocytes, in newborn mice.
Heeg K, Bendigs S, Wagner H. Heeg K, et al. Scand J Immunol. 1989 Dec;30(6):703-10. doi: 10.1111/j.1365-3083.1989.tb02479.x. Scand J Immunol. 1989. PMID: 2602913
Immunity to mycobacteria: possible role of alpha/beta and gamma/delta T lymphocytes.
Munk ME, Gatrill AJ, Schoel B, Gulle H, Pfeffer K, Wagner H, Kaufmann SH. Munk ME, et al. APMIS. 1990 Aug;98(8):669-73. doi: 10.1111/j.1699-0463.1990.tb04987.x. APMIS. 1990. PMID: 2206513 Review.
A major fraction of human intraepithelial lymphocytes simultaneously expresses the gamma/delta T cell receptor, the CD8 accessory molecule and preferentially uses the V delta 1 gene segment.
Deusch K, Lüling F, Reich K, Classen M, Wagner H, Pfeffer K. Deusch K, et al. Eur J Immunol. 1991 Apr;21(4):1053-9. doi: 10.1002/eji.1830210429. Eur J Immunol. 1991. PMID: 1826884
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