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347 results
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p53 stabilization is decreased upon NFkappaB activation: a role for NFkappaB in acquisition of resistance to chemotherapy.
Tergaonkar V, Pando M, Vafa O, Wahl G, Verma I. Tergaonkar V, et al. Among authors: wahl g. Cancer Cell. 2002 Jun;1(5):493-503. doi: 10.1016/s1535-6108(02)00068-5. Cancer Cell. 2002. PMID: 12124178
Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity.
Dravis C, Chung CY, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM. Dravis C, et al. Among authors: wahl gm. Cancer Cell. 2018 Sep 10;34(3):466-482.e6. doi: 10.1016/j.ccell.2018.08.001. Epub 2018 Aug 30. Cancer Cell. 2018. PMID: 30174241 Free PMC article.
MDM2 and MDM4: p53 regulators as targets in anticancer therapy.
Toledo F, Wahl GM. Toledo F, et al. Int J Biochem Cell Biol. 2007;39(7-8):1476-82. doi: 10.1016/j.biocel.2007.03.022. Epub 2007 Apr 8. Int J Biochem Cell Biol. 2007. PMID: 17499002 Free PMC article. Review.
Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation.
Wang YV, Wade M, Wong E, Li YC, Rodewald LW, Wahl GM. Wang YV, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12365-70. doi: 10.1073/pnas.0701497104. Epub 2007 Jul 17. Proc Natl Acad Sci U S A. 2007. PMID: 17640893 Free PMC article.
MDM2, MDMX and p53 in oncogenesis and cancer therapy.
Wade M, Li YC, Wahl GM. Wade M, et al. Nat Rev Cancer. 2013 Feb;13(2):83-96. doi: 10.1038/nrc3430. Epub 2013 Jan 10. Nat Rev Cancer. 2013. PMID: 23303139 Free PMC article. Review.
The p53 orchestra: Mdm2 and Mdmx set the tone.
Wade M, Wang YV, Wahl GM. Wade M, et al. Trends Cell Biol. 2010 May;20(5):299-309. doi: 10.1016/j.tcb.2010.01.009. Epub 2010 Feb 19. Trends Cell Biol. 2010. PMID: 20172729 Free PMC article. Review.
Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases.
Wang YV, Leblanc M, Wade M, Jochemsen AG, Wahl GM. Wang YV, et al. Among authors: wahl gm. Cancer Cell. 2009 Jul 7;16(1):33-43. doi: 10.1016/j.ccr.2009.05.008. Cancer Cell. 2009. PMID: 19573810 Free PMC article.
Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression.
Toledo F, Lee CJ, Krummel KA, Rodewald LW, Liu CW, Wahl GM. Toledo F, et al. Mol Cell Biol. 2007 Feb;27(4):1425-32. doi: 10.1128/MCB.00999-06. Epub 2006 Dec 11. Mol Cell Biol. 2007. PMID: 17158931 Free PMC article.
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas.
Toledo F, Wahl GM. Toledo F, et al. Nat Rev Cancer. 2006 Dec;6(12):909-23. doi: 10.1038/nrc2012. Nat Rev Cancer. 2006. PMID: 17128209 Review.
The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation.
Krummel KA, Lee CJ, Toledo F, Wahl GM. Krummel KA, et al. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10188-93. doi: 10.1073/pnas.0503068102. Epub 2005 Jul 8. Proc Natl Acad Sci U S A. 2005. PMID: 16006521 Free PMC article.
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