Wahl G - Search Results

1

Genetic instability, oncogenes, and the p53 pathway.

Wahl G, Vafa O. Wahl G, et al. Cold Spring Harb Symp Quant Biol. 2000;65:511-20. doi: 10.1101/sqb.2000.65.511. Cold Spring Harb Symp Quant Biol. 2000. PMID: 12760068 Review. No abstract available.

2

Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity.

Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. Turner KM, et al. Nature. 2017 Mar 2;543(7643):122-125. doi: 10.1038/nature21356. Epub 2017 Feb 8. Nature. 2017. PMID: 28178237 Free PMC article.

3

Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity.

Dravis C, Chung CY, Lytle NK, Herrera-Valdez J, Luna G, Trejo CL, Reya T, Wahl GM. Dravis C, et al. Among authors: wahl gm. Cancer Cell. 2018 Sep 10;34(3):466-482.e6. doi: 10.1016/j.ccell.2018.08.001. Epub 2018 Aug 30. Cancer Cell. 2018. PMID: 30174241 Free PMC article.

4

Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation.

Wang YV, Wade M, Wong E, Li YC, Rodewald LW, Wahl GM. Wang YV, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12365-70. doi: 10.1073/pnas.0701497104. Epub 2007 Jul 17. Proc Natl Acad Sci U S A. 2007. PMID: 17640893 Free PMC article.

5

The p53 orchestra: Mdm2 and Mdmx set the tone.

Wade M, Wang YV, Wahl GM. Wade M, et al. Trends Cell Biol. 2010 May;20(5):299-309. doi: 10.1016/j.tcb.2010.01.009. Epub 2010 Feb 19. Trends Cell Biol. 2010. PMID: 20172729 Free PMC article. Review.

6

Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases.

Wang YV, Leblanc M, Wade M, Jochemsen AG, Wahl GM. Wang YV, et al. Among authors: wahl gm. Cancer Cell. 2009 Jul 7;16(1):33-43. doi: 10.1016/j.ccr.2009.05.008. Cancer Cell. 2009. PMID: 19573810 Free PMC article.

7

Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression.

Toledo F, Lee CJ, Krummel KA, Rodewald LW, Liu CW, Wahl GM. Toledo F, et al. Mol Cell Biol. 2007 Feb;27(4):1425-32. doi: 10.1128/MCB.00999-06. Epub 2006 Dec 11. Mol Cell Biol. 2007. PMID: 17158931 Free PMC article.

8

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation.

Krummel KA, Lee CJ, Toledo F, Wahl GM. Krummel KA, et al. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10188-93. doi: 10.1073/pnas.0503068102. Epub 2005 Jul 8. Proc Natl Acad Sci U S A. 2005. PMID: 16006521 Free PMC article.

9

Targeting Mdm2 and Mdmx in cancer therapy: better living through medicinal chemistry?

Wade M, Wahl GM. Wade M, et al. Mol Cancer Res. 2009 Jan;7(1):1-11. doi: 10.1158/1541-7786.MCR-08-0423. Mol Cancer Res. 2009. PMID: 19147532 Free PMC article. Review.

10

A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.

Toledo F, Krummel KA, Lee CJ, Liu CW, Rodewald LW, Tang M, Wahl GM. Toledo F, et al. Cancer Cell. 2006 Apr;9(4):273-85. doi: 10.1016/j.ccr.2006.03.014. Cancer Cell. 2006. PMID: 16616333

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