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Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity.
Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. Turner KM, et al. Nature. 2017 Mar 2;543(7643):122-125. doi: 10.1038/nature21356. Epub 2017 Feb 8. Nature. 2017. PMID: 28178237 Free PMC article.
Recent progress in understanding mechanisms of mammalian DNA amplification.
Stark GR, Debatisse M, Giulotto E, Wahl GM. Stark GR, et al. Cell. 1989 Jun 16;57(6):901-8. doi: 10.1016/0092-8674(89)90328-0. Cell. 1989. PMID: 2661014 Review. No abstract available.
Gene amplification.
Stark GR, Wahl GM. Stark GR, et al. Annu Rev Biochem. 1984;53:447-91. doi: 10.1146/ Annu Rev Biochem. 1984. PMID: 6383198 Review. No abstract available.
A branching process model of gene amplification following chromosome breakage.
Kimmel M, Axelrod DE, Wahl GM. Kimmel M, et al. Mutat Res. 1992 May;276(3):225-39. doi: 10.1016/0165-1110(92)90010-7. Mutat Res. 1992. PMID: 1374516
Induction of differentiation in HL60 cells by the reduction of extrachromosomally amplified c-myc.
Eckhardt SG, Dai A, Davidson KK, Forseth BJ, Wahl GM, Von Hoff DD. Eckhardt SG, et al. Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6674-8. doi: 10.1073/pnas.91.14.6674. Proc Natl Acad Sci U S A. 1994. PMID: 8022834 Free PMC article.
Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity.
Von Hoff DD, McGill JR, Forseth BJ, Davidson KK, Bradley TP, Van Devanter DR, Wahl GM. Von Hoff DD, et al. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8165-9. doi: 10.1073/pnas.89.17.8165. Proc Natl Acad Sci U S A. 1992. PMID: 1518843 Free PMC article.
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