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Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity.
Turner KM, Deshpande V, Beyter D, Koga T, Rusert J, Lee C, Li B, Arden K, Ren B, Nathanson DA, Kornblum HI, Taylor MD, Kaushal S, Cavenee WK, Wechsler-Reya R, Furnari FB, Vandenberg SR, Rao PN, Wahl GM, Bafna V, Mischel PS. Turner KM, et al. Nature. 2017 Mar 2;543(7643):122-125. doi: 10.1038/nature21356. Epub 2017 Feb 8. Nature. 2017. PMID: 28178237 Free PMC article.
Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation.
Wang YV, Wade M, Wong E, Li YC, Rodewald LW, Wahl GM. Wang YV, et al. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12365-70. doi: 10.1073/pnas.0701497104. Epub 2007 Jul 17. Proc Natl Acad Sci U S A. 2007. PMID: 17640893 Free PMC article.
Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression.
Toledo F, Lee CJ, Krummel KA, Rodewald LW, Liu CW, Wahl GM. Toledo F, et al. Mol Cell Biol. 2007 Feb;27(4):1425-32. doi: 10.1128/MCB.00999-06. Epub 2006 Dec 11. Mol Cell Biol. 2007. PMID: 17158931 Free PMC article.
The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation.
Krummel KA, Lee CJ, Toledo F, Wahl GM. Krummel KA, et al. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10188-93. doi: 10.1073/pnas.0503068102. Epub 2005 Jul 8. Proc Natl Acad Sci U S A. 2005. PMID: 16006521 Free PMC article.
Use of a molecular genetic platform technology to produce human Wnt proteins reveals distinct local and distal signaling abilities.
Green JL, Bauer M, Yum KW, Li YC, Cox ML, Willert K, Wahl GM. Green JL, et al. PLoS One. 2013;8(3):e58395. doi: 10.1371/journal.pone.0058395. Epub 2013 Mar 13. PLoS One. 2013. PMID: 23516471 Free PMC article.
Genetic instability, oncogenes, and the p53 pathway.
Wahl G, Vafa O. Wahl G, et al. Cold Spring Harb Symp Quant Biol. 2000;65:511-20. doi: 10.1101/sqb.2000.65.511. Cold Spring Harb Symp Quant Biol. 2000. PMID: 12760068 Review. No abstract available.
Genetic dissection of a mammalian replicator in the human beta-globin locus.
Aladjem MI, Rodewald LW, Kolman JL, Wahl GM. Aladjem MI, et al. Science. 1998 Aug 14;281(5379):1005-9. doi: 10.1126/science.281.5379.1005. Science. 1998. PMID: 9703500
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