Wakefield LM - Search Results

1

Transforming growth factor-beta and breast cancer: Lessons learned from genetically altered mouse models.

Wakefield LM, Yang YA, Dukhanina O. Wakefield LM, et al. Breast Cancer Res. 2000;2(2):100-6. doi: 10.1186/bcr41. Epub 2000 Feb 21. Breast Cancer Res. 2000. PMID: 11250699 Free PMC article. Review.

2

Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects.

Yang YA, Dukhanina O, Tang B, Mamura M, Letterio JJ, MacGregor J, Patel SC, Khozin S, Liu ZY, Green J, Anver MR, Merlino G, Wakefield LM. Yang YA, et al. Among authors: wakefield lm. J Clin Invest. 2002 Jun;109(12):1607-15. doi: 10.1172/JCI15333. J Clin Invest. 2002. PMID: 12070308 Free PMC article.

3

A novel approach for the generation of genetically modified mammary epithelial cell cultures yields new insights into TGFβ signaling in the mammary gland.

Kohn EA, Du Z, Sato M, Van Schyndle CM, Welsh MA, Yang YA, Stuelten CH, Tang B, Ju W, Bottinger EP, Wakefield LM. Kohn EA, et al. Among authors: wakefield lm. Breast Cancer Res. 2010;12(5):R83. doi: 10.1186/bcr2728. Epub 2010 Oct 13. Breast Cancer Res. 2010. PMID: 20942910 Free PMC article.

4

Smad3 in the mammary epithelium has a nonredundant role in the induction of apoptosis, but not in the regulation of proliferation or differentiation by transforming growth factor-beta.

Yang YA, Tang B, Robinson G, Hennighausen L, Brodie SG, Deng CX, Wakefield LM. Yang YA, et al. Among authors: wakefield lm. Cell Growth Differ. 2002 Mar;13(3):123-30. Cell Growth Differ. 2002. PMID: 11959813

5

Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17.

Nam JS, Terabe M, Kang MJ, Chae H, Voong N, Yang YA, Laurence A, Michalowska A, Mamura M, Lonning S, Berzofsky JA, Wakefield LM. Nam JS, et al. Among authors: wakefield lm. Cancer Res. 2008 May 15;68(10):3915-23. doi: 10.1158/0008-5472.CAN-08-0206. Cancer Res. 2008. PMID: 18483277 Free PMC article.

6

Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression.

Kohn EA, Yang YA, Du Z, Nagano Y, Van Schyndle CM, Herrmann MA, Heldman M, Chen JQ, Stuelten CH, Flanders KC, Wakefield LM. Kohn EA, et al. Among authors: wakefield lm. Mol Cancer Res. 2012 Oct;10(10):1389-99. doi: 10.1158/1541-7786.MCR-12-0136-T. Epub 2012 Aug 9. Mol Cancer Res. 2012. PMID: 22878587 Free PMC article.

7

An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-β in human breast cancer.

Sato M, Kadota M, Tang B, Yang HH, Yang YA, Shan M, Weng J, Welsh MA, Flanders KC, Nagano Y, Michalowski AM, Clifford RJ, Lee MP, Wakefield LM. Sato M, et al. Among authors: wakefield lm. Breast Cancer Res. 2014 Jun 2;16(3):R57. doi: 10.1186/bcr3668. Breast Cancer Res. 2014. PMID: 24890385 Free PMC article.

8

The Outcome of TGFβ Antagonism in Metastatic Breast Cancer Models In Vivo Reflects a Complex Balance between Tumor-Suppressive and Proprogression Activities of TGFβ.

Yang Y, Yang HH, Tang B, Wu AML, Flanders KC, Moshkovich N, Weinberg DS, Welsh MA, Weng J, Ochoa HJ, Hu TY, Herrmann MA, Chen J, Edmondson EF, Simpson RM, Liu F, Liu H, Lee MP, Wakefield LM. Yang Y, et al. Among authors: wakefield lm. Clin Cancer Res. 2020 Feb 1;26(3):643-656. doi: 10.1158/1078-0432.CCR-19-2370. Epub 2019 Oct 3. Clin Cancer Res. 2020. PMID: 31582516 Free PMC article.

9

Identification of the start sites for the 1.9- and 1.4-kb rat transforming growth factor-beta1 transcripts and their effect on translational efficiency.

Yang Y, Mumy M, Romeo D, Wakefield LM. Yang Y, et al. Among authors: wakefield lm. Gene. 1998 Sep 28;219(1-2):81-9. doi: 10.1016/s0378-1119(98)00402-8. Gene. 1998. PMID: 9757003

10

Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer.

Nam JS, Suchar AM, Kang MJ, Stuelten CH, Tang B, Michalowska AM, Fisher LW, Fedarko NS, Jain A, Pinkas J, Lonning S, Wakefield LM. Nam JS, et al. Among authors: wakefield lm. Cancer Res. 2006 Jun 15;66(12):6327-35. doi: 10.1158/0008-5472.CAN-06-0068. Cancer Res. 2006. PMID: 16778210 Free PMC article.

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