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Establishment of FUT8 knockout Chinese hamster ovary cells: an ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity.
Yamane-Ohnuki N, Kinoshita S, Inoue-Urakubo M, Kusunoki M, Iida S, Nakano R, Wakitani M, Niwa R, Sakurada M, Uchida K, Shitara K, Satoh M. Yamane-Ohnuki N, et al. Among authors: wakitani m. Biotechnol Bioeng. 2004 Sep 5;87(5):614-22. doi: 10.1002/bit.20151. Biotechnol Bioeng. 2004. PMID: 15352059
Fucose removal from complex-type oligosaccharide enhances the antibody-dependent cellular cytotoxicity of single-gene-encoded antibody comprising a single-chain antibody linked the antibody constant region.
Natsume A, Wakitani M, Yamane-Ohnuki N, Shoji-Hosaka E, Niwa R, Uchida K, Satoh M, Shitara K. Natsume A, et al. Among authors: wakitani m. J Immunol Methods. 2005 Nov 30;306(1-2):93-103. doi: 10.1016/j.jim.2005.07.025. Epub 2005 Oct 3. J Immunol Methods. 2005. PMID: 16236307
Double knockdown of alpha1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC.
Imai-Nishiya H, Mori K, Inoue M, Wakitani M, Iida S, Shitara K, Satoh M. Imai-Nishiya H, et al. Among authors: wakitani m. BMC Biotechnol. 2007 Nov 30;7:84. doi: 10.1186/1472-6750-7-84. BMC Biotechnol. 2007. PMID: 18047682 Free PMC article.
Fucose removal from complex-type oligosaccharide enhances the antibody-dependent cellular cytotoxicity of single-gene-encoded bispecific antibody comprising of two single-chain antibodies linked to the antibody constant region.
Natsume A, Wakitani M, Yamane-Ohnuki N, Shoji-Hosaka E, Niwa R, Uchida K, Satoh M, Shitara K. Natsume A, et al. Among authors: wakitani m. J Biochem. 2006 Sep;140(3):359-68. doi: 10.1093/jb/mvj157. Epub 2006 Jul 21. J Biochem. 2006. PMID: 16861252
15 results