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Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis.
Wald A, Link K. Wald A, et al. J Infect Dis. 2002 Jan 1;185(1):45-52. doi: 10.1086/338231. Epub 2001 Dec 14. J Infect Dis. 2002. PMID: 11756980
To determine the contribution of herpes simplex type 2 (HSV-2) infection to the risk of human immunodeficiency virus (HIV) acquisition, a systematic review of literature and data synthesis were done. ...Control strategies for HSV-2 need to be incorporated into control of s …
To determine the contribution of herpes simplex type 2 (HSV-2) infection to the risk of human immunodeficiency virus (HIV) acquisition, a
Suppression of subclinical shedding of herpes simplex virus type 2 with acyclovir.
Wald A, Zeh J, Barnum G, Davis LG, Corey L. Wald A, et al. Ann Intern Med. 1996 Jan 1;124(1 Pt 1):8-15. doi: 10.7326/0003-4819-124-1_part_1-199601010-00002. Ann Intern Med. 1996. PMID: 7503497 Clinical Trial.
DESIGN: A double-blind, placebo-controlled, crossover clinical trial. SETTING: A university-based virology research clinic. PATIENTS: 34 women with herpes simplex virus type 2 (HSV-2) antibody only and genital herpes of less than 2 years' duration. ...In a pa …
DESIGN: A double-blind, placebo-controlled, crossover clinical trial. SETTING: A university-based virology research clinic. PA …
Virologic characteristics of subclinical and symptomatic genital herpes infections.
Wald A, Zeh J, Selke S, Ashley RL, Corey L. Wald A, et al. N Engl J Med. 1995 Sep 21;333(12):770-5. doi: 10.1056/NEJM199509213331205. N Engl J Med. 1995. PMID: 7643884
Half the episodes of subclinical shedding of HSV occurred within seven days of a symptomatic recurrence. The risk of subclinical shedding increased with the frequency of symptomatic recurrences. ...CONCLUSIONS: Among women with a history of genital herpes infection, …
Half the episodes of subclinical shedding of HSV occurred within seven days of a symptomatic recurrence. The risk of subclinical shed …
Seroprevalence of herpes simplex virus infections in a family medicine clinic.
Oliver L, Wald A, Kim M, Zeh J, Selke S, Ashley R, Corey L. Oliver L, et al. Arch Fam Med. 1995 Mar;4(3):228-32. doi: 10.1001/archfami.4.3.228. Arch Fam Med. 1995. PMID: 7881604
OBJECTIVES: To determine the prevalence of herpes simplex virus (HSV) antibody in a general medical practice setting and to assess the frequency of subclinical infection. ...The specificity of a clinical history of genital herpes or sores for HSV-2 infection was hig …
OBJECTIVES: To determine the prevalence of herpes simplex virus (HSV) antibody in a general medical practice setting and to assess th …
Cervical antibodies in patients with oral herpes simplex virus type 1 (HSV-1) infection: local anamnestic responses after genital HSV-2 infection.
Ashley R, Wald A, Corey L. Ashley R, et al. J Virol. 1994 Aug;68(8):5284-6. doi: 10.1128/JVI.68.8.5284-5286.1994. J Virol. 1994. PMID: 8035526 Free PMC article.
Herpes simplex virus (HSV)-specific immunoglobulin A, immunoglobulin G, and secretory-component-containing immunoglobulins were identified in cervical and salivary secretions from six subjects with oral HSV type 1 (HSV-1) infections. ...
Herpes simplex virus (HSV)-specific immunoglobulin A, immunoglobulin G, and secretory-component-containing immunoglobulins were ident …
A randomized, double-blind, comparative trial comparing high- and standard-dose oral acyclovir for first-episode genital herpes infections.
Wald A, Benedetti J, Davis G, Remington M, Winter C, Corey L. Wald A, et al. Antimicrob Agents Chemother. 1994 Feb;38(2):174-6. doi: 10.1128/aac.38.2.174. Antimicrob Agents Chemother. 1994. PMID: 8192438 Free PMC article. Clinical Trial.
We investigated in a randomized, double-blind, comparative trial whether a higher (4 g) than standard (1 g) daily dose of oral acyclovir results in greater clinical benefit and influences the time to first recurrence. A total of 139 patients with first-episod …
We investigated in a randomized, double-blind, comparative trial whether a higher (4 g) than standard (1 g) daily dose of oral …
Evaluation of a quantitative competitive PCR assay for measuring herpes simplex virus DNA content in genital tract secretions.
Hobson A, Wald A, Wright N, Corey L. Hobson A, et al. J Clin Microbiol. 1997 Mar;35(3):548-52. doi: 10.1128/JCM.35.3.548-552.1997. J Clin Microbiol. 1997. PMID: 9041386 Free PMC article.
To control for variance in amplification conditions, we developed a competitive quantitative PCR (QC PCR) for the detection of HSV DNA. ...A single swab with secretions from all three genital sites and evaluated in a QC PCR format can accurately measure the f …
To control for variance in amplification conditions, we developed a competitive quantitative PCR (QC PCR) for the detection of HSV DN …
Frequent genital herpes simplex virus 2 shedding in immunocompetent women. Effect of acyclovir treatment.
Wald A, Corey L, Cone R, Hobson A, Davis G, Zeh J. Wald A, et al. J Clin Invest. 1997 Mar 1;99(5):1092-7. doi: 10.1172/JCI119237. J Clin Invest. 1997. PMID: 9062368 Free PMC article. Clinical Trial.
Daily samples of genital secretions were obtained from 27 HSV-2 seropositive women; a subset of subjects obtained samples while receiving oral acyclovir 400 mg PO twice a day. ...This frequent reactivation likely plays a role in the epidemic spread of genital …
Daily samples of genital secretions were obtained from 27 HSV-2 seropositive women; a subset of subjects obtained samples while recei …
Genital herpes in a primary care clinic. Demographic and sexual correlates of herpes simplex type 2 infections.
Wald A, Koutsky L, Ashley RL, Corey L. Wald A, et al. Sex Transm Dis. 1997 Mar;24(3):149-55. doi: 10.1097/00007435-199703000-00005. Sex Transm Dis. 1997. PMID: 9132981
STUDY DESIGN: Cross-sectional survey of 922 randomly chosen patients and 78 of their partners (1,000 total) in a family practice. ...Among white women, number of sexual partners, a prior STD, marriage or cohabitation, and less than a college education were pr …
STUDY DESIGN: Cross-sectional survey of 922 randomly chosen patients and 78 of their partners (1,000 total) in a family practice. ... …
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