Walden H - Search Results

1

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.

Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM. Kondapalli C, et al. Among authors: walden h. Open Biol. 2012 May;2(5):120080. doi: 10.1098/rsob.120080. Open Biol. 2012. PMID: 22724072 Free PMC article.

2

Structural and biochemical basis of interdependent FANCI-FANCD2 ubiquitination.

Lemonidis K, Rennie ML, Arkinson C, Chaugule VK, Clarke M, Streetley J, Walden H. Lemonidis K, et al. Among authors: walden h. EMBO J. 2023 Feb 1;42(3):e111898. doi: 10.15252/embj.2022111898. Epub 2022 Nov 17. EMBO J. 2023. PMID: 36385258 Free PMC article.

3

Autoregulation of Parkin activity through its ubiquitin-like domain.

Chaugule VK, Burchell L, Barber KR, Sidhu A, Leslie SJ, Shaw GS, Walden H. Chaugule VK, et al. Among authors: walden h. EMBO J. 2011 Jun 21;30(14):2853-67. doi: 10.1038/emboj.2011.204. EMBO J. 2011. PMID: 21694720 Free PMC article.

4

Small, N-terminal tags activate Parkin E3 ubiquitin ligase activity by disrupting its autoinhibited conformation.

Burchell L, Chaugule VK, Walden H. Burchell L, et al. Among authors: walden h. PLoS One. 2012;7(4):e34748. doi: 10.1371/journal.pone.0034748. Epub 2012 Apr 4. PLoS One. 2012. PMID: 22496854 Free PMC article.

5

Regulation of Parkin E3 ubiquitin ligase activity.

Walden H, Martinez-Torres RJ. Walden H, et al. Cell Mol Life Sci. 2012 Sep;69(18):3053-67. doi: 10.1007/s00018-012-0978-5. Epub 2012 Apr 19. Cell Mol Life Sci. 2012. PMID: 22527713 Review.

6

A molecular explanation for the recessive nature of parkin-linked Parkinson's disease.

Spratt DE, Martinez-Torres RJ, Noh YJ, Mercier P, Manczyk N, Barber KR, Aguirre JD, Burchell L, Purkiss A, Walden H, Shaw GS. Spratt DE, et al. Among authors: walden h. Nat Commun. 2013;4:1983. doi: 10.1038/ncomms2983. Nat Commun. 2013. PMID: 23770917 Free PMC article.

7

RBR E3 ubiquitin ligases: new structures, new insights, new questions.

Spratt DE, Walden H, Shaw GS. Spratt DE, et al. Among authors: walden h. Biochem J. 2014 Mar 15;458(3):421-37. doi: 10.1042/BJ20140006. Biochem J. 2014. PMID: 24576094 Free PMC article. Review.

8

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, Walden H, Muqit MM. Kazlauskaite A, et al. Among authors: walden h. EMBO Rep. 2015 Aug;16(8):939-54. doi: 10.15252/embr.201540352. Epub 2015 Jun 25. EMBO Rep. 2015. PMID: 26116755 Free PMC article.

9

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.

Kumar A, Aguirre JD, Condos TE, Martinez-Torres RJ, Chaugule VK, Toth R, Sundaramoorthy R, Mercier P, Knebel A, Spratt DE, Barber KR, Shaw GS, Walden H. Kumar A, et al. Among authors: walden h. EMBO J. 2015 Oct 14;34(20):2506-21. doi: 10.15252/embj.201592337. Epub 2015 Aug 7. EMBO J. 2015. PMID: 26254304 Free PMC article.

10

Ubiquitin and Parkinson's disease through the looking glass of genetics.

Walden H, Muqit MM. Walden H, et al. Biochem J. 2017 Apr 13;474(9):1439-1451. doi: 10.1042/BCJ20160498. Biochem J. 2017. PMID: 28408429 Free PMC article. Review.

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