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The significance of "nonsignificance" in randomized controlled studies: a discussion inspired by a double-blinded study on St. John's wort (Hypericum perforatum L.) for premenstrual symptoms.
Hicks SM, Walker AF, Gallagher J, Middleton RW, Wright J. Hicks SM, et al. J Altern Complement Med. 2004 Dec;10(6):925-32. doi: 10.1089/acm.2004.10.925. J Altern Complement Med. 2004. PMID: 15673985 Clinical Trial.
Unexpected benefit of sorbitol placebo in Mg intervention study of premenstrual symptoms: implications for choice of placebo in RCTs.
Walker AF, De Souza MC, Marakis G, Robinson PA, Morris AP, Bolland KM. Walker AF, et al. Med Hypotheses. 2002 Mar;58(3):213-20. doi: 10.1054/mehy.2001.1407. Med Hypotheses. 2002. PMID: 12018972 Clinical Trial.
Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: a randomized, double blind placebo controlled trial.
Bundy R, Walker AF, Middleton RW, Wallis C, Simpson HC. Bundy R, et al. Phytomedicine. 2008 Sep;15(9):668-75. doi: 10.1016/j.phymed.2008.03.001. Phytomedicine. 2008. PMID: 18424099 Clinical Trial.
Artichoke leaf extract reduces mild dyspepsia in an open study.
Marakis G, Walker AF, Middleton RW, Booth JC, Wright J, Pike DJ. Marakis G, et al. Phytomedicine. 2002 Dec;9(8):694-9. doi: 10.1078/094471102321621287. Phytomedicine. 2002. PMID: 12587688 Clinical Trial.
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