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Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS.
Narvaez AJ, Ber S, Crooks A, Emery A, Hardwick B, Guarino Almeida E, Huggins DJ, Perera D, Roberts-Thomson M, Azzarelli R, Hood FE, Prior IA, Walker DW, Boyce R, Boyle RG, Barker SP, Torrance CJ, McKenzie GJ, Venkitaraman AR. Narvaez AJ, et al. Among authors: walker dw. Cell Chem Biol. 2017 Aug 17;24(8):1017-1028.e7. doi: 10.1016/j.chembiol.2017.07.009. Epub 2017 Aug 10. Cell Chem Biol. 2017. PMID: 28807782 Free PMC article.
Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1.
Huggins DJ, Hardwick BS, Sharma P, Emery A, Laraia L, Zhang F, Narvaez AJ, Roberts-Thomson M, Crooks AT, Boyle RG, Boyce R, Walker DW, Mateu N, McKenzie GJ, Spring DR, Venkitaraman AR. Huggins DJ, et al. Among authors: walker dw. ACS Omega. 2019 Dec 24;5(1):822-831. doi: 10.1021/acsomega.9b03626. eCollection 2020 Jan 14. ACS Omega. 2019. PMID: 31956833 Free PMC article.
Preparation of kinase-biased compounds in the search for lead inhibitors of kinase targets.
Lai JY, Langston S, Adams R, Beevers RE, Boyce R, Burckhardt S, Cobb J, Ferguson Y, Figueroa E, Grimster N, Henry AH, Khan N, Jenkins K, Jones MW, Judkins R, Major J, Masood A, Nally J, Payne H, Payne L, Raphy G, Raynham T, Reader J, Reader V, Reid A, Ruprah P, Shaw M, Sore H, Stirling M, Talbot A, Taylor J, Thompson S, Wada H, Walker D. Lai JY, et al. Med Res Rev. 2005 May;25(3):310-30. doi: 10.1002/med.20026. Med Res Rev. 2005. PMID: 15593285 Review.
Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria.
Zhou Z, Ma A, Moore TM, Wolf DM, Yang N, Tran P, Segawa M, Strumwasser AR, Ren W, Fu K, Wanagat J, van der Bliek AM, Crosbie-Watson R, Liesa M, Stiles L, Acin-Perez R, Mahata S, Shirihai O, Goodarzi MO, Handzlik M, Metallo CM, Walker DW, Hevener AL. Zhou Z, et al. Among authors: walker dw. Sci Adv. 2024 Apr 5;10(14):eadl0389. doi: 10.1126/sciadv.adl0389. Epub 2024 Apr 3. Sci Adv. 2024. PMID: 38569044 Free PMC article.
396 results