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Did you mean alkmycn (1 results)?
New natural products to meet the antibiotic crisis: a personal journey.
Igarashi M. Igarashi M. J Antibiot (Tokyo). 2019 Dec;72(12):890-898. doi: 10.1038/s41429-019-0224-6. Epub 2019 Aug 28. J Antibiot (Tokyo). 2019. PMID: 31462681 Review.
In the present review, antimicrobial resistance (AMR) is briefly introduced and research focused on the identification and characterization of actinomycete metabolites for antimicrobial activity is discussed. Three compounds, i.e., walkmycin B, waldiomycin, and signamycin …
In the present review, antimicrobial resistance (AMR) is briefly introduced and research focused on the identification and characterization …
Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth.
Okada A, Igarashi M, Okajima T, Kinoshita N, Umekita M, Sawa R, Inoue K, Watanabe T, Doi A, Martin A, Quinn J, Nishimura Y, Utsumi R. Okada A, et al. J Antibiot (Tokyo). 2010 Feb;63(2):89-94. doi: 10.1038/ja.2009.128. Epub 2010 Jan 8. J Antibiot (Tokyo). 2010. PMID: 20057515
MICs of walkmycin B against B. subtilis and S. aureus were 0.39 and 0.20 microg ml(-1), and IC(50) measurements against WalK were 1.6 and 5.7 microM, respectively. ...These results suggest that walkmycin B inhibits WalK autophosphorylation by binding to the WalK cyt …
MICs of walkmycin B against B. subtilis and S. aureus were 0.39 and 0.20 microg ml(-1), and IC(50) measurements against WalK were 1.6 …
Development of an antivirulence drug against Streptococcus mutans: repression of biofilm formation, acid tolerance, and competence by a histidine kinase inhibitor, walkmycin C.
Eguchi Y, Kubo N, Matsunaga H, Igarashi M, Utsumi R. Eguchi Y, et al. Antimicrob Agents Chemother. 2011 Apr;55(4):1475-84. doi: 10.1128/AAC.01646-10. Epub 2011 Jan 31. Antimicrob Agents Chemother. 2011. PMID: 21282451 Free PMC article.
The object of this study was to evaluate the effect of a histidine kinase (HK) inhibitor against two major virulence factors of S. mutans: biofilm formation and acid tolerance. Walkmycin C (WKM C), an HK inhibitor isolated from the screening of inhibitors against WalK HK i …
The object of this study was to evaluate the effect of a histidine kinase (HK) inhibitor against two major virulence factors of S. mutans: b …